Marchand C - Search Results

1

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C. Pommier Y, et al. Among authors: marchand c. DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. DNA Repair (Amst). 2014. PMID: 24856239 Free PMC article. Review.

2

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Dexheimer TS, Antony S, Marchand C, Pommier Y. Dexheimer TS, et al. Among authors: marchand c. Anticancer Agents Med Chem. 2008 May;8(4):381-9. doi: 10.2174/187152008784220357. Anticancer Agents Med Chem. 2008. PMID: 18473723 Free PMC article. Review.

3

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.

Huang SN, Pommier Y, Marchand C. Huang SN, et al. Among authors: marchand c. Expert Opin Ther Pat. 2011 Sep;21(9):1285-92. doi: 10.1517/13543776.2011.604314. Expert Opin Ther Pat. 2011. PMID: 21843105 Free PMC article. Review.

4

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.

Gao R, Huang SY, Marchand C, Pommier Y. Gao R, et al. Among authors: marchand c. J Biol Chem. 2012 Aug 31;287(36):30842-52. doi: 10.1074/jbc.M112.393983. Epub 2012 Jul 20. J Biol Chem. 2012. PMID: 22822062 Free PMC article.

5

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.

Murai J, Marchand C, Shahane SA, Sun H, Huang R, Zhang Y, Chergui A, Ji J, Doroshow JH, Jadhav A, Takeda S, Xia M, Pommier Y. Murai J, et al. Among authors: marchand c. DNA Repair (Amst). 2014 Sep;21:177-82. doi: 10.1016/j.dnarep.2014.03.006. Epub 2014 Apr 29. DNA Repair (Amst). 2014. PMID: 24794403 Free PMC article.

6

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

Gao R, Schellenberg MJ, Huang SY, Abdelmalak M, Marchand C, Nitiss KC, Nitiss JL, Williams RS, Pommier Y. Gao R, et al. Among authors: marchand c. J Biol Chem. 2014 Jun 27;289(26):17960-9. doi: 10.1074/jbc.M114.565374. Epub 2014 May 7. J Biol Chem. 2014. PMID: 24808172 Free PMC article.

7

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.

8

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y. Marchand C, et al. ACS Chem Biol. 2016 Jul 15;11(7):1925-33. doi: 10.1021/acschembio.5b01047. Epub 2016 May 11. ACS Chem Biol. 2016. PMID: 27128689 Free PMC article.

9

Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3'- and 5'-phosphodiester-DNA bond cleavage.

Kiselev E, Dexheimer TS, Marchand C, Huang SN, Pommier Y. Kiselev E, et al. Among authors: marchand c. DNA Repair (Amst). 2018 Jun-Jul;66-67:64-71. doi: 10.1016/j.dnarep.2018.05.001. Epub 2018 May 2. DNA Repair (Amst). 2018. PMID: 29747024 Free PMC article.

10

Interfacial inhibitors of protein-nucleic acid interactions.

Pommier Y, Marchand C. Pommier Y, et al. Among authors: marchand c. Curr Med Chem Anticancer Agents. 2005 Jul;5(4):421-9. doi: 10.2174/1568011054222337. Curr Med Chem Anticancer Agents. 2005. PMID: 16101492 Review.

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