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Heterogeneity of Circulating Tumor Cell-Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response.
Kanwar N, Balde Z, Nair R, Dawe M, Chen S, Maganti M, Atenafu EG, Manolescu S, Wei C, Mao A, Fu F, Wang D, Cheung A, Yerofeyeva Y, Peters R, Liu K, Desmedt C, Sotiriou C, Szekely B, Kulka J, McKee TD, Hirano N, Bartlett JMS, Yaffe MJ, Bedard PL, McCready D, Done SJ. Kanwar N, et al. Among authors: mao a. Cancer Res. 2021 Dec 15;81(24):6196-6206. doi: 10.1158/0008-5472.CAN-21-1079. Epub 2021 Oct 28. Cancer Res. 2021. PMID: 34711609 Free PMC article.
Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors.
Mo Q, Zhong T, Cao B, Han Z, Hu X, Zhao S, Wei X, Yang Z, Qin J. Mo Q, et al. Eur J Med Chem. 2024 May 3;272:116474. doi: 10.1016/j.ejmech.2024.116474. Online ahead of print. Eur J Med Chem. 2024. PMID: 38735149
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately needed. Monoamine oxidase A (MAO-A)-activated therapeutic and diagnostic compounds provide great selectivity because …
Small molecule photosensitizers for combined in vivo tailored cancer diagnostics and photodynamic/photothermal therapy are desperately neede …
Kinetic modeling of the monoamine oxidase-B radioligand [(18)F]SMBT-1 in human brain with positron emission tomography.
Lopresti BJ, Stehouwer J, Reese AC, Mason NS, Royse SK, Narendran R, Laymon CM, Lopez OL, Cohen AD, Mathis CA, Villemagne VL. Lopresti BJ, et al. J Cereb Blood Flow Metab. 2024 May 12:271678X241254679. doi: 10.1177/0271678X241254679. Online ahead of print. J Cereb Blood Flow Metab. 2024. PMID: 38735059
This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [(18)F](S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline ([(18)F]SMBT-1) for positron emission tomography (PET) brain imaging. ...
This paper describes pharmacokinetic analyses of the monoamine-oxidase-B (MAO-B) radiotracer [(18)F](S)-(2-methylpyrid-5-yl)-6 …
Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: Alleviation of hippocampal synaptic dysfunction, Tau pathology and amyloidogenesis.
Saleh SR, Abd-Elmegied A, Aly Madhy S, Khattab SN, Sheta E, Elnozahy FY, Mehanna RA, Ghareeb DA, Abd-Elmonem NM. Saleh SR, et al. Int J Pharm. 2024 May 9:124218. doi: 10.1016/j.ijpharm.2024.124218. Online ahead of print. Int J Pharm. 2024. PMID: 38734273
Cognitive improvement was assessed using the Morris Water Maze. Brain acetylcholinesterase and monoamine oxidase activities, amyloid beta42 (Abeta42), and brain glycemic markers were estimated. ...
Cognitive improvement was assessed using the Morris Water Maze. Brain acetylcholinesterase and monoamine oxidase activities, a …
Enantiodivergent kinetic resolution of 4-substituted 1,2,3,4-tetrahydroquinolines employing amine oxidase.
Jin H, Wang Z, Pu Z, Yu H, Chen Y, Zhou X, Yang L, Ju S, Wu J. Jin H, et al. Int J Biol Macromol. 2024 May 8:132102. doi: 10.1016/j.ijbiomac.2024.132102. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38729465
Through structure-guided protein engineering of cyclohexylamine oxidase derived from Brevibacterium oxidans IH-35 A (CHAO), the variant of CHAO (Y215H/Y214S) displayed improved specific activity toward model substrate 4-phenyl substituted THQ (0.14 U/mg, 13-fold higher tha …
Through structure-guided protein engineering of cyclohexylamine oxidase derived from Brevibacterium oxidans IH-35 A (CHAO), the varia …
Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.
Elkamhawy A, Oh JM, Kim M, El-Halaby LO, Abdellattif MH, Al-Karmalawy AA, Kim H, Lee K. Elkamhawy A, et al. Mol Divers. 2024 May 10. doi: 10.1007/s11030-024-10841-9. Online ahead of print. Mol Divers. 2024. PMID: 38727994
Herein, a novel series of naphthamide derivatives has been rationally developed, synthesized, and evaluated for their inhibitory activity against monoamine oxidase (MAO) and cholinesterase (ChE) enzymes. Compared to the reported naphthalene-based hit IV, the new nap …
Herein, a novel series of naphthamide derivatives has been rationally developed, synthesized, and evaluated for their inhibitory activity ag …
In Vivo Reactive Astrocyte Imaging in Patients With Schizophrenia Using Fluorine 18-Labeled THK5351.
Kim M, Choi W, Choi S, Oh H, Kim J, Lee J, An SJ, Hwang JS, Lee YS, Song IC, Moon SY, Lho SK, Cho SS, Kwon JS. Kim M, et al. JAMA Netw Open. 2024 May 1;7(5):e2410684. doi: 10.1001/jamanetworkopen.2024.10684. JAMA Netw Open. 2024. PMID: 38722627 Free PMC article.
OBJECTIVE: To investigate in vivo reactive astrocytes in patients with schizophrenia associated with positive symptoms using monoamine oxidase B (MAO-B)-binding fluorine 18 ([18F])-labeled THK5351 positron emission tomography (PET). ...
OBJECTIVE: To investigate in vivo reactive astrocytes in patients with schizophrenia associated with positive symptoms using monoamine …
Ferulago Angulata methanolic extract ameliorates scopolamine-induced memory impairment through the inhibition of hippocampal monoamine oxidase activity.
Hajimohammadi S, Soodi M, Hajimehdipoor H, Sefidbakht S, Mashhadi Sharif N. Hajimohammadi S, et al. Metab Brain Dis. 2024 May 9. doi: 10.1007/s11011-024-01353-4. Online ahead of print. Metab Brain Dis. 2024. PMID: 38722561
Starting on the sixth day of treatment, the Morris water maze behavioral study was conducted to evaluate cognitive function, with scopolamine administered 30 min before training. Biochemical assays, including monoamine oxidase and oxidative stress measures, were per …
Starting on the sixth day of treatment, the Morris water maze behavioral study was conducted to evaluate cognitive function, with scopolamin …
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