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Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library.
Canal-Martín A, Sastre J, Sánchez-Barrena MJ, Canales A, Baldominos S, Pascual N, Martínez-González L, Molero D, Fernández-Valle ME, Sáez E, Blanco-Gabella P, Gómez-Rubio E, Martín-Santamaría S, Sáiz A, Mansilla A, Cañada FJ, Jiménez-Barbero J, Martínez A, Pérez-Fernández R. Canal-Martín A, et al. Among authors: mansilla a. Nat Commun. 2019 Jun 26;10(1):2798. doi: 10.1038/s41467-019-10627-w. Nat Commun. 2019. PMID: 31243268 Free PMC article.
Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.
Mansilla A, Chaves-Sanjuan A, Campillo NE, Semelidou O, Martínez-González L, Infantes L, González-Rubio JM, Gil C, Conde S, Skoulakis EM, Ferrús A, Martínez A, Sánchez-Barrena MJ. Mansilla A, et al. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E999-E1008. doi: 10.1073/pnas.1611089114. Epub 2017 Jan 24. Proc Natl Acad Sci U S A. 2017. PMID: 28119500 Free PMC article.
Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators.
Roca C, Martinez-González L, Daniel-Mozo M, Sastre J, Infantes L, Mansilla A, Chaves-Sanjuan A, González-Rubio JM, Gil C, Cañada FJ, Martinez A, Sanchez-Barrena MJ, Campillo NE. Roca C, et al. Among authors: mansilla a. J Med Chem. 2018 Jul 26;61(14):5910-5921. doi: 10.1021/acs.jmedchem.8b00088. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 29966094
The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes.
Cogram P, Fernández-Beltrán LC, Casarejos MJ, Sánchez-Yepes S, Rodríguez-Martín E, García-Rubia A, Sánchez-Barrena MJ, Gil C, Martínez A, Mansilla A. Cogram P, et al. Among authors: mansilla a. Front Neurosci. 2022 Nov 16;16:1007531. doi: 10.3389/fnins.2022.1007531. eCollection 2022. Front Neurosci. 2022. PMID: 36466176 Free PMC article.
The guanine-exchange factor Ric8a binds to the Ca²⁺ sensor NCS-1 to regulate synapse number and neurotransmitter release.
Romero-Pozuelo J, Dason JS, Mansilla A, Baños-Mateos S, Sardina JL, Chaves-Sanjuán A, Jurado-Gómez J, Santana E, Atwood HL, Hernández-Hernández Á, Sánchez-Barrena MJ, Ferrús A. Romero-Pozuelo J, et al. Among authors: mansilla a. J Cell Sci. 2014 Oct 1;127(Pt 19):4246-59. doi: 10.1242/jcs.152603. Epub 2014 Jul 29. J Cell Sci. 2014. PMID: 25074811 Free article.
Molecular mechanisms that change synapse number.
Mansilla A, Jordán-Álvarez S, Santana E, Jarabo P, Casas-Tintó S, Ferrús A. Mansilla A, et al. J Neurogenet. 2018 Sep;32(3):155-170. doi: 10.1080/01677063.2018.1506781. Epub 2018 Oct 10. J Neurogenet. 2018. PMID: 30303424 Review.
136 results