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Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity.
Hateley C, Olona A, Halliday L, Edin ML, Ko JH, Forlano R, Terra X, Lih FB, Beltrán-Debón R, Manousou P, Purkayastha S, Moorthy K, Thursz MR, Zhang G, Goldin RD, Zeldin DC, Petretto E, Behmoaras J. Hateley C, et al. Among authors: manousou p. EBioMedicine. 2024 May;103:105127. doi: 10.1016/j.ebiom.2024.105127. Epub 2024 Apr 26. EBioMedicine. 2024. PMID: 38677183 Free PMC article.
A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis.
Harrison SA, Bedossa P, Guy CD, Schattenberg JM, Loomba R, Taub R, Labriola D, Moussa SE, Neff GW, Rinella ME, Anstee QM, Abdelmalek MF, Younossi Z, Baum SJ, Francque S, Charlton MR, Newsome PN, Lanthier N, Schiefke I, Mangia A, Pericàs JM, Patil R, Sanyal AJ, Noureddin M, Bansal MB, Alkhouri N, Castera L, Rudraraju M, Ratziu V; MAESTRO-NASH Investigators. Harrison SA, et al. N Engl J Med. 2024 Feb 8;390(6):497-509. doi: 10.1056/NEJMoa2309000. N Engl J Med. 2024. PMID: 38324483 Clinical Trial.
Detection of senescence using machine learning algorithms based on nuclear features.
Duran I, Pombo J, Sun B, Gallage S, Kudo H, McHugh D, Bousset L, Barragan Avila JE, Forlano R, Manousou P, Heikenwalder M, Withers DJ, Vernia S, Goldin RD, Gil J. Duran I, et al. Among authors: manousou p. Nat Commun. 2024 Feb 3;15(1):1041. doi: 10.1038/s41467-024-45421-w. Nat Commun. 2024. PMID: 38310113 Free PMC article.
Translating the potential of the urine steroid metabolome to stage NAFLD (TrUSt-NAFLD): study protocol for a multicentre, prospective validation study.
Miller H, Harman D, Aithal GP, Manousou P, Cobbold JF, Parker R, Sheridan D, Newsome PN, Karpe F, Neville M, Arlt W, Sitch AJ, Korbonits M, Biehl M, Alazawi W, Tomlinson JW. Miller H, et al. Among authors: manousou p. BMJ Open. 2024 Jan 18;14(1):e074918. doi: 10.1136/bmjopen-2023-074918. BMJ Open. 2024. PMID: 38238179 Free PMC article.
Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus.
Forlano R, Martinez-Gili L, Takis P, Miguens-Blanco J, Liu T, Triantafyllou E, Skinner C, Loomba R, Thursz M, Marchesi JR, Mullish BH, Manousou P. Forlano R, et al. Among authors: manousou p. Gut Microbes. 2024 Jan-Dec;16(1):2304157. doi: 10.1080/19490976.2024.2304157. Epub 2024 Jan 18. Gut Microbes. 2024. PMID: 38235661 Free PMC article.
Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients.
Murray SM, Pose E, Wittner M, Londoño MC, Schaub G, Cook J, Dimitriadis S, Meacham G, Irwin S, Lim Z, Duengelhoef P, Sterneck M, Lohse AW, Perez V, Trivedi P, Bhandal K, Mullish BH, Manousou P, Provine NM, Avitabile E, Carroll M, Tipton T, Healy S, Burra P, Klenerman P, Dunachie S, Kronsteiner B, Maciola AK, Pasqual G, Hernandez-Gea V, Garcia-Pagan JC, Lampertico P, Iavarone M, Gines P, Lütgehetmann M, Schulze Zur Wiesch J, Russo FP, Barnes E, Marjot T; OCTAVE Collaborative Group, PITCH study, and the EASL supported COVID-Hep vaccine network. Murray SM, et al. Among authors: manousou p. J Hepatol. 2024 Jan;80(1):109-123. doi: 10.1016/j.jhep.2023.10.009. Epub 2023 Oct 19. J Hepatol. 2024. PMID: 37863203 Free PMC article.
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