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Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Jamshidiha M, Lanyon-Hogg T, Sutherell CL, Craven GB, Tersa M, De Vita E, Brustur D, Pérez-Dorado I, Hassan S, Petracca R, Morgan RM, Sanz-Hernández M, Norman JC, Armstrong A, Mann DJ, Cota E, Tate EW. Jamshidiha M, et al. Among authors: mann dj. RSC Med Chem. 2021 Dec 16;13(2):150-155. doi: 10.1039/d1md00225b. eCollection 2022 Feb 23. RSC Med Chem. 2021. PMID: 35308027 Free PMC article.
Protein myristoylation in health and disease.
Wright MH, Heal WP, Mann DJ, Tate EW. Wright MH, et al. Among authors: mann dj. J Chem Biol. 2010 Mar;3(1):19-35. doi: 10.1007/s12154-009-0032-8. Epub 2009 Nov 7. J Chem Biol. 2010. PMID: 19898886 Free PMC article.
Kinetic template-guided tethering of fragments.
Nonoo RH, Armstrong A, Mann DJ. Nonoo RH, et al. Among authors: mann dj. ChemMedChem. 2012 Dec;7(12):2082-6. doi: 10.1002/cmdc.201200404. Epub 2012 Oct 2. ChemMedChem. 2012. PMID: 23033251
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Wright MH, et al. Among authors: mann dj. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. Nat Chem. 2014. PMID: 24451586 Free PMC article.
High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJ. Craven GB, et al. Among authors: mann dj. Angew Chem Int Ed Engl. 2018 May 4;57(19):5257-5261. doi: 10.1002/anie.201711825. Epub 2018 Mar 26. Angew Chem Int Ed Engl. 2018. PMID: 29480525 Free PMC article.
101 results