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The N-glycome regulates the endothelial-to-hematopoietic transition.
Kasper DM, Hintzen J, Wu Y, Ghersi JJ, Mandl HK, Salinas KE, Armero W, He Z, Sheng Y, Xie Y, Heindel DW, Park EJ, Sessa WC, Mahal LK, Lebrilla C, Hirschi KK, Nicoli S. Kasper DM, et al. Among authors: mandl hk. Science. 2020 Dec 4;370(6521):1186-1191. doi: 10.1126/science.aaz2121. Epub 2020 Dec 3. Science. 2020. PMID: 33273096 Free PMC article.
Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.
Kudalkar SN, Ullah I, Bertoletti N, Mandl HK, Cisneros JA, Beloor J, Chan AH, Quijano E, Saltzman WM, Jorgensen WL, Kumar P, Anderson KS. Kudalkar SN, et al. Among authors: mandl hk. Antiviral Res. 2019 Jul;167:110-116. doi: 10.1016/j.antiviral.2019.04.010. Epub 2019 Apr 26. Antiviral Res. 2019. PMID: 31034849 Free PMC article.
Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model.
Beloor J, Kudalkar SN, Buzzelli G, Yang F, Mandl HK, Rajashekar JK, Spasov KA, Jorgensen WL, Saltzman WM, Anderson KS, Kumar P. Beloor J, et al. Among authors: mandl hk. Bioeng Transl Med. 2021 Jun 26;7(1):e10237. doi: 10.1002/btm2.10237. eCollection 2022 Jan. Bioeng Transl Med. 2021. PMID: 35079625 Free PMC article.
Nanoparticles for delivery of agents to fetal lungs.
Ullrich SJ, Freedman-Weiss M, Ahle S, Mandl HK, Piotrowski-Daspit AS, Roberts K, Yung N, Maassel N, Bauer-Pisani T, Ricciardi AS, Egan ME, Glazer PM, Saltzman WM, Stitelman DH. Ullrich SJ, et al. Among authors: mandl hk. Acta Biomater. 2021 Mar 15;123:346-353. doi: 10.1016/j.actbio.2021.01.024. Epub 2021 Jan 21. Acta Biomater. 2021. PMID: 33484911 Free PMC article.
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance.
Wang Y, Jiang Y, Wei D, Singh P, Yu Y, Lee T, Zhang L, Mandl HK, Piotrowski-Daspit AS, Chen X, Li F, Li X, Cheng Y, Josowitz A, Yang F, Zhao Y, Wang F, Zhao Z, Huttner A, Bindra RS, Xiao H, Mark Saltzman W. Wang Y, et al. Among authors: mandl hk. Nat Biomed Eng. 2021 Sep;5(9):1048-1058. doi: 10.1038/s41551-021-00728-7. Epub 2021 May 27. Nat Biomed Eng. 2021. PMID: 34045730 Free PMC article.
Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.
Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. Abt ER, et al. Among authors: mandl hk. J Clin Invest. 2022 Aug 15;132(16):e160852. doi: 10.1172/JCI160852. J Clin Invest. 2022. PMID: 35653193 Free PMC article.