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Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway.
Pierdominici M, Giammarioli AM, Gambardella L, De Felice M, Quinti I, Iacobini M, Carbonari M, Malorni W, Giovannetti A. Pierdominici M, et al. Among authors: malorni w. J Pharmacol Exp Ther. 2005 Dec;315(3):1046-57. doi: 10.1124/jpet.105.086736. Epub 2005 Sep 12. J Pharmacol Exp Ther. 2005. PMID: 16157660
Unravelling the complexity of T cell abnormalities in common variable immunodeficiency.
Giovannetti A, Pierdominici M, Mazzetta F, Marziali M, Renzi C, Mileo AM, De Felice M, Mora B, Esposito A, Carello R, Pizzuti A, Paggi MG, Paganelli R, Malorni W, Aiuti F. Giovannetti A, et al. Among authors: malorni w. J Immunol. 2007 Mar 15;178(6):3932-43. doi: 10.4049/jimmunol.178.6.3932. J Immunol. 2007. PMID: 17339494 Clinical Trial.
Progressive derangement of the T cell compartment in a case of Evans syndrome.
Giovannetti A, Pierdominici M, Esposito A, Cagliuso M, Stifano G, Giammarioli AM, Maselli A, Malorni W, Salsano F, Aiuti F. Giovannetti A, et al. Among authors: malorni w. Int Arch Allergy Immunol. 2008;145(3):258-67. doi: 10.1159/000109295. Epub 2007 Oct 5. Int Arch Allergy Immunol. 2008. PMID: 17921676
Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis.
Margutti P, Matarrese P, Conti F, Colasanti T, Delunardo F, Capozzi A, Garofalo T, Profumo E, Riganò R, Siracusano A, Alessandri C, Salvati B, Valesini G, Malorni W, Sorice M, Ortona E. Margutti P, et al. Among authors: malorni w. Blood. 2008 May 1;111(9):4559-70. doi: 10.1182/blood-2007-05-092825. Epub 2007 Nov 9. Blood. 2008. PMID: 17993611 Free PMC article.
380 results