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Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant.
Arvizu-Flores AA, Sugich-Miranda R, Arreola R, Garcia-Orozco KD, Velazquez-Contreras EF, Montfort WR, Maley F, Sotelo-Mundo RR. Arvizu-Flores AA, et al. Among authors: maley f. Int J Biochem Cell Biol. 2008;40(10):2206-17. doi: 10.1016/j.biocel.2008.02.025. Epub 2008 Mar 6. Int J Biochem Cell Biol. 2008. PMID: 18403248 Free PMC article.
Functional identity of the active sites of crustacean and viral thymidylate synthases.
Arvizu-Flores AA, Aispuro-Hernandez E, Garcia-Orozco KD, Varela-Romero A, Valenzuela-Soto E, Velazquez-Contreras EF, Rojo-Domínguez A, Yepiz-Plascencia G, Maley F, Sotelo-Mundo RR. Arvizu-Flores AA, et al. Among authors: maley f. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep;150(3):406-13. doi: 10.1016/j.cbpc.2009.06.008. Epub 2009 Jun 25. Comp Biochem Physiol C Toxicol Pharmacol. 2009. PMID: 19559812
Structure of the Y94F mutant of Escherichia coli thymidylate synthase.
Roberts SA, Hyatt DC, Honts JE, Changchien L, Maley GF, Maley F, Montfort WR. Roberts SA, et al. Among authors: maley f, maley gf. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):840-3. doi: 10.1107/S1744309106029691. Epub 2006 Aug 18. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16946460 Free PMC article.
Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.
Lobo AP, Nair MG, Changchien L, Weichsel A, Montfort WR, Maley F. Lobo AP, et al. Among authors: maley f. Biochemistry. 1998 Mar 31;37(13):4535-42. doi: 10.1021/bi9717284. Biochemistry. 1998. PMID: 9521774
Similar to previously described Lactobacillus casei TS inhibition studies with sulfhydryl reagents [Galivan, J., Noonan, J., and Maley, F. (1977) Arch. Biochem. Biophys. 184, 336-345], the kinetics of inhibition suggested that complete inhibition occurs on reaction …
Similar to previously described Lactobacillus casei TS inhibition studies with sulfhydryl reagents [Galivan, J., Noonan, J., and Maley …
218 results