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MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.
Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP. Ahn B, et al. Among authors: malany s. J Clin Invest. 2016 Sep 1;126(9):3567-79. doi: 10.1172/JCI87382. Epub 2016 Aug 8. J Clin Invest. 2016. PMID: 27500491 Free PMC article.
Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms.
Sugarman E, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Soundarapandian MM, Vega RB, Kelly DP, Smith LH, Malany S. Sugarman E, et al. Among authors: malany s. J Biomol Screen. 2014 Jan;19(1):77-87. doi: 10.1177/1087057113501198. Epub 2013 Aug 29. J Biomol Screen. 2014. PMID: 23989452 Free PMC article.
Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.
Sangaralingham SJ, Whig K, Peddibhotla S, Kirby RJ, Sessions HE, Maloney PR, Hershberger PM, Mose-Yates H, Hood BL, Vasile S, Pan S, Zheng Y, Malany S, Burnett JC Jr. Sangaralingham SJ, et al. Among authors: malany s. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2109386118. doi: 10.1073/pnas.2109386118. Proc Natl Acad Sci U S A. 2021. PMID: 34930837 Free PMC article.
Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma.
Peddibhotla S, Hershberger PM, Jason Kirby R, Sugarman E, Maloney PR, Hampton Sessions E, Divlianska D, Morfa CJ, Terry D, Pinkerton AB, Smith LH, Malany S. Peddibhotla S, et al. Among authors: malany s. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126899. doi: 10.1016/j.bmcl.2019.126899. Epub 2019 Dec 17. Bioorg Med Chem Lett. 2020. PMID: 31882297 Free PMC article.
Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes.
Peddibhotla S, Fontaine P, Leung CK, Maloney P, Hershberger PM, Wang Y, Bousquet MS, Luesch H, Mangravita-Novo A, Pinkerton AB, Smith LH, Malany S, Choe K. Peddibhotla S, et al. Among authors: malany s. ACS Chem Biol. 2015 Aug 21;10(8):1871-9. doi: 10.1021/acschembio.5b00304. Epub 2015 May 22. ACS Chem Biol. 2015. PMID: 25946346
50 results