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Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.
Tang C, Sun H, Kadoki M, Han W, Ye X, Makusheva Y, Deng J, Feng B, Qiu D, Tan Y, Wang X, Guo Z, Huang C, Peng S, Chen M, Adachi Y, Ohno N, Trombetta S, Iwakura Y. Tang C, et al. Among authors: makusheva y. Nat Commun. 2023 Mar 17;14(1):1493. doi: 10.1038/s41467-023-37229-x. Nat Commun. 2023. PMID: 36932082 Free PMC article.
The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17.
Makusheva Y, Chung SH, Akitsu A, Maeda N, Maruhashi T, Ye XQ, Kaifu T, Saijo S, Sun H, Han W, Tang C, Iwakura Y. Makusheva Y, et al. Exp Anim. 2022 Aug 5;71(3):288-304. doi: 10.1538/expanim.21-0191. Epub 2022 May 8. Exp Anim. 2022. PMID: 35135958 Free PMC article.