Maklad RM - Search Results

1

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens.

Al-Warhi T, Elimam DM, Elsayed ZM, Abdel-Aziz MM, Maklad RM, Al-Karmalawy AA, Afarinkia K, Abourehab MAS, Abdel-Aziz HA, Eldehna WM. Al-Warhi T, et al. Among authors: maklad rm. RSC Adv. 2022 Nov 2;12(48):31466-31477. doi: 10.1039/d2ra04385h. eCollection 2022 Oct 27. RSC Adv. 2022. PMID: 36382148 Free PMC article.

2

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells.

Al-Sanea MM, Al-Ansary GH, Elsayed ZM, Maklad RM, Elkaeed EB, Abdelgawad MA, Bukhari SNA, Abdel-Aziz MM, Suliman H, Eldehna WM. Al-Sanea MM, et al. Among authors: maklad rm. J Enzyme Inhib Med Chem. 2021 Dec;36(1):987-999. doi: 10.1080/14756366.2021.1915302. J Enzyme Inhib Med Chem. 2021. PMID: 33985397 Free PMC article.

3

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights.

Eldehna WM, Maklad RM, Almahli H, Al-Warhi T, Elkaeed EB, Abourehab MAS, Abdel-Aziz HA, El Kerdawy AM. Eldehna WM, et al. Among authors: maklad rm. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1227-1240. doi: 10.1080/14756366.2022.2062337. J Enzyme Inhib Med Chem. 2022. PMID: 35470754 Free PMC article.

4

1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights.

Al-Warhi T, Almahli H, Maklad RM, Elsayed ZM, El Hassab MA, Alotaibi OJ, Aljaeed N, Ayyad RR, Ghabour HA, Eldehna WM, El-Ashrey MK. Al-Warhi T, et al. Among authors: maklad rm. Molecules. 2023 Apr 4;28(7):3203. doi: 10.3390/molecules28073203. Molecules. 2023. PMID: 37049966 Free PMC article.

5

Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation.

Ibrahim TM, Abada G, Dammann M, Maklad RM, Eldehna WM, Salem R, Abdelaziz MM, El-Domany RA, Bekhit AA, Beockler FM. Ibrahim TM, et al. Among authors: maklad rm. Eur J Med Chem. 2023 Sep 5;257:115534. doi: 10.1016/j.ejmech.2023.115534. Epub 2023 May 29. Eur J Med Chem. 2023. PMID: 37269671

6

Thieno[2,3-c]isoquinolines: A novel chemotype of antiproliferative agents inducing cellular apoptosis while targeting the G2/M phase and Tubulin.

Marae IS, Maklad RM, Samir S, Bakhite EA, Sharmoukh W. Marae IS, et al. Among authors: maklad rm. Drug Dev Res. 2023 Jun;84(4):747-766. doi: 10.1002/ddr.22054. Epub 2023 Mar 31. Drug Dev Res. 2023. PMID: 36999479

7

Synthesis, cytotoxicity, docking study, and tubulin polymerization inhibitory activity of novel 1-(3,4-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxanilides.

Aly OM, Beshr EA, Maklad RM, Mustafa M, Gamal-Eldeen AM. Aly OM, et al. Among authors: maklad rm. Arch Pharm (Weinheim). 2014 Sep;347(9):658-67. doi: 10.1002/ardp.201400096. Epub 2014 Jul 3. Arch Pharm (Weinheim). 2014. PMID: 24996189

8

Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker.

Maklad RM, AbdelHafez EMN, Abdelhamid D, Aly OM. Maklad RM, et al. Bioorg Chem. 2020 Jun;99:103767. doi: 10.1016/j.bioorg.2020.103767. Epub 2020 Apr 6. Bioorg Chem. 2020. PMID: 32325332

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