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Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease.
Zaręba P, Łątka K, Mazur G, Gryzło B, Pasieka A, Godyń J, Panek D, Skrzypczak-Wiercioch A, Höfner GC, Latacz G, Maj M, Espargaró A, Sabaté R, Jóźwiak K, Wanner KT, Sałat K, Malawska B, Kulig K, Bajda M. Zaręba P, et al. Among authors: maj m. Eur J Med Chem. 2023 Dec 5;261:115832. doi: 10.1016/j.ejmech.2023.115832. Epub 2023 Oct 7. Eur J Med Chem. 2023. PMID: 37837674 Free article.
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.
Chioua M, Buzzi E, Moraleda I, Iriepa I, Maj M, Wnorowski A, Giovannini C, Tramarin A, Portali F, Ismaili L, López-Alvarado P, Bolognesi ML, Jóźwiak K, Menéndez JC, Marco-Contelles J, Bartolini M. Chioua M, et al. Among authors: maj m. Eur J Med Chem. 2018 Jul 15;155:839-846. doi: 10.1016/j.ejmech.2018.06.044. Epub 2018 Jun 19. Eur J Med Chem. 2018. PMID: 29958119
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.
Zaręba P, Sałat K, Höfner GC, Łątka K, Bajda M, Latacz G, Kotniewicz K, Rapacz A, Podkowa A, Maj M, Jóźwiak K, Filipek B, Wanner KT, Malawska B, Kulig K. Zaręba P, et al. Among authors: maj m. Eur J Med Chem. 2021 Oct 5;221:113512. doi: 10.1016/j.ejmech.2021.113512. Epub 2021 May 4. Eur J Med Chem. 2021. PMID: 34015586
Type I and type II positive allosteric modulators of α7 nicotinic acetylcholine receptors induce antidepressant-like activity in mice by a mechanism involving receptor potentiation but not neurotransmitter reuptake inhibition. Correlation with mTOR intracellular pathway activation.
Targowska-Duda KM, Budzynska B, Michalak A, Wnorowski A, Loland CJ, Maj M, Manetti D, Romanelli MN, Jozwiak K, Biala G, Arias HR. Targowska-Duda KM, et al. Among authors: maj m. Eur Neuropsychopharmacol. 2021 Nov;52:31-47. doi: 10.1016/j.euroneuro.2021.06.006. Epub 2021 Jul 6. Eur Neuropsychopharmacol. 2021. PMID: 34237657
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
Malek R, Simakov A, Davis A, Maj M, Bernard PJ, Wnorowski A, Martin H, Marco-Contelles J, Chabchoub F, Dallemagne P, Rochais C, Jozwiak K, Ismaili L. Malek R, et al. Among authors: maj m. Molecules. 2022 Dec 22;28(1):71. doi: 10.3390/molecules28010071. Molecules. 2022. PMID: 36615267 Free PMC article.
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties.
Pachón-Angona I, Bernard PJ, Simakov A, Maj M, Jozwiak K, Novotna A, Lemke C, Gütschow M, Martin H, Oset-Gasque MJ, Contelles JM, Ismaili L. Pachón-Angona I, et al. Among authors: maj m. Pharmaceutics. 2024 Jan 17;16(1):121. doi: 10.3390/pharmaceutics16010121. Pharmaceutics. 2024. PMID: 38258131 Free PMC article.
744 results