Mahul-Mellier AL - Search Results

1

Amyloid single-cell cytotoxicity assays by nanomotion detection.

Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G. Ruggeri FS, et al. Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017. Cell Death Discov. 2017. PMID: 28845298 Free PMC article.

2

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. Khalaf O, et al. J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936070 Free PMC article.

3

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.

Benmessaoud IR, Mahul-Mellier AL, Horváth E, Maco B, Spina M, Lashuel HA, Forró L. Benmessaoud IR, et al. Toxicol Res (Camb). 2015 Nov 25;5(2):407-419. doi: 10.1039/c5tx00303b. eCollection 2016 Mar 1. Toxicol Res (Camb). 2015. PMID: 30090356 Free PMC article.

4

The Nt17 Domain and its Helical Conformation Regulate the Aggregation, Cellular Properties and Neurotoxicity of Mutant Huntingtin Exon 1.

Vieweg S, Mahul-Mellier AL, Ruggeri FS, Riguet N, DeGuire SM, Chiki A, Cendrowska U, Dietler G, Lashuel HA. Vieweg S, et al. Among authors: mahul mellier al. J Mol Biol. 2021 Oct 15;433(21):167222. doi: 10.1016/j.jmb.2021.167222. Epub 2021 Sep 4. J Mol Biol. 2021. PMID: 34492254 Free article.

5

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.

Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR. Levine PM, et al. Among authors: mahul mellier al. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1511-1519. doi: 10.1073/pnas.1808845116. Epub 2019 Jan 16. Proc Natl Acad Sci U S A. 2019. PMID: 30651314 Free PMC article.

6

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. Mahul-Mellier AL, et al. Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9. Hum Mol Genet. 2014. PMID: 24412932 Free PMC article.

7

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Dikiy I, et al. ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11. ACS Chem Biol. 2016. PMID: 27356045 Free PMC article.

8

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA. Ait-Bouziad N, et al. Nat Commun. 2017 Nov 22;8(1):1678. doi: 10.1038/s41467-017-01575-4. Nat Commun. 2017. PMID: 29162800 Free PMC article.

9

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.

Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA. Mahul-Mellier AL, et al. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4971-4982. doi: 10.1073/pnas.1913904117. Epub 2020 Feb 19. Proc Natl Acad Sci U S A. 2020. PMID: 32075919 Free PMC article.

10

A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.

Kumar ST, Mahul-Mellier AL, Hegde RN, Rivière G, Moons R, Ibáñez de Opakua A, Magalhães P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA. Kumar ST, et al. Among authors: mahul mellier al. Sci Adv. 2022 Apr 29;8(17):eabn0044. doi: 10.1126/sciadv.abn0044. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486726 Free PMC article.

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