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Page 1
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.
Tai YH, Engels D, Locatelli G, Emmanouilidis I, Fecher C, Theodorou D, Müller SA, Licht-Mayer S, Kreutzfeldt M, Wagner I, de Mello NP, Gkotzamani SN, Trovò L, Kendirli A, Aljović A, Breckwoldt MO, Naumann R, Bareyre FM, Perocchi F, Mahad D, Merkler D, Lichtenthaler SF, Kerschensteiner M, Misgeld T. Tai YH, et al. Among authors: mahad d. Nat Metab. 2023 Aug;5(8):1364-1381. doi: 10.1038/s42255-023-00838-3. Epub 2023 Jul 10. Nat Metab. 2023. PMID: 37430025 Free PMC article.
Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.
Cronin SJF, Yu W, Hale A, Licht-Mayer S, Crabtree MJ, Korecka JA, Tretiakov EO, Sealey-Cardona M, Somlyay M, Onji M, An M, Fox JD, Turnes BL, Gomez-Diaz C, da Luz Scheffer D, Cikes D, Nagy V, Weidinger A, Wolf A, Reither H, Chabloz A, Kavirayani A, Rao S, Andrews N, Latremoliere A, Costigan M, Douglas G, Freitas FC, Pifl C, Walz R, Konrat R, Mahad DJ, Koslov AV, Latini A, Isacson O, Harkany T, Hallett PJ, Bagby S, Woolf CJ, Channon KM, Je HS, Penninger JM. Cronin SJF, et al. Among authors: mahad dj. bioRxiv [Preprint]. 2023 May 8:2023.05.08.539795. doi: 10.1101/2023.05.08.539795. bioRxiv. 2023. PMID: 37214873 Free PMC article. Preprint.
Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis.
Licht-Mayer S, Campbell GR, Mehta AR, McGill K, Symonds A, Al-Azki S, Pryce G, Zandee S, Zhao C, Kipp M, Smith KJ, Baker D, Altmann D, Anderton SM, Kap YS, Laman JD, 't Hart BA, Rodriguez M, Franklin RJM, Chandran S, Lassmann H, Trapp BD, Mahad DJ. Licht-Mayer S, et al. Among authors: mahad dj. Neuropathol Appl Neurobiol. 2023 Feb;49(1):e12851. doi: 10.1111/nan.12851. Epub 2022 Oct 7. Neuropathol Appl Neurobiol. 2023. PMID: 36181265 Free PMC article.
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
Mehta AR, Gregory JM, Dando O, Carter RN, Burr K, Nanda J, Story D, McDade K, Smith C, Morton NM, Mahad DJ, Hardingham GE, Chandran S, Selvaraj BT. Mehta AR, et al. Among authors: mahad dj. Acta Neuropathol. 2021 Feb;141(2):257-279. doi: 10.1007/s00401-020-02252-5. Epub 2021 Jan 4. Acta Neuropathol. 2021. PMID: 33398403 Free PMC article.
Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Cree BAC, Cutter G, Wolinsky JS, Freedman MS, Comi G, Giovannoni G, Hartung HP, Arnold D, Kuhle J, Block V, Munschauer FE, Sedel F, Lublin FD; SPI2 investigative teams. Cree BAC, et al. Lancet Neurol. 2020 Dec;19(12):988-997. doi: 10.1016/S1474-4422(20)30347-1. Epub 2020 Oct 23. Lancet Neurol. 2020. PMID: 33222767 Clinical Trial.
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.
Cunniffe N, Vuong KA, Ainslie D, Baker D, Beveridge J, Bickley S, Camilleri P, Craner M, Fitzgerald D, de la Fuente AG, Giovannoni G, Gray E, Hazlehurst L, Kapoor R, Kaur R, Kozlowski D, Lumicisi B, Mahad D, Neumann B, Palmer A, Peruzzotti-Jametti L, Pluchino S, Robertson J, Rothaul A, Shellard L, Smith KJ, Wilkins A, Williams A, Coles A. Cunniffe N, et al. Among authors: mahad d. J Neurol Neurosurg Psychiatry. 2021 Mar;92(3):295-302. doi: 10.1136/jnnp-2020-324286. Epub 2020 Nov 12. J Neurol Neurosurg Psychiatry. 2021. PMID: 33184094
Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis.
Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K, Ghosh A, Fullerton A, Menezes N, Dean J, Dunham J, Al-Azki S, Pryce G, Zandee S, Zhao C, Kipp M, Smith KJ, Baker D, Altmann D, Anderton SM, Kap YS, Laman JD, Hart BA', Rodriguez M, Watzlawick R, Schwab JM, Carter R, Morton N, Zagnoni M, Franklin RJM, Mitchell R, Fleetwood-Walker S, Lyons DA, Chandran S, Lassmann H, Trapp BD, Mahad DJ. Licht-Mayer S, et al. Among authors: mahad dj. Acta Neuropathol. 2020 Aug;140(2):143-167. doi: 10.1007/s00401-020-02179-x. Epub 2020 Jun 22. Acta Neuropathol. 2020. PMID: 32572598 Free PMC article.
72 results