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Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y, Wu H. Sharif H, et al. Among authors: magupalli vg. Nature. 2019 Jun;570(7761):338-343. doi: 10.1038/s41586-019-1295-z. Epub 2019 Jun 12. Nature. 2019. PMID: 31189953 Free PMC article.
Crystal structure of the WD40 domain dimer of LRRK2.
Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. Zhang P, et al. Among authors: magupalli vg. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1579-1584. doi: 10.1073/pnas.1817889116. Epub 2019 Jan 11. Proc Natl Acad Sci U S A. 2019. PMID: 30635421 Free PMC article.
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Among authors: magupalli vg. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. Magupalli VG, et al. Science. 2020 Sep 18;369(6510):eaas8995. doi: 10.1126/science.aas8995. Science. 2020. PMID: 32943500 Free PMC article.
Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Xia S, et al. Among authors: magupalli vg. Nature. 2021 May;593(7860):607-611. doi: 10.1038/s41586-021-03478-3. Epub 2021 Apr 21. Nature. 2021. PMID: 33883744 Free PMC article.
NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions.
Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. Münzer P, et al. Among authors: magupalli vg. Front Immunol. 2021 May 28;12:683803. doi: 10.3389/fimmu.2021.683803. eCollection 2021. Front Immunol. 2021. PMID: 34122445 Free PMC article.
18 results