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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. Yin Z, et al. Among authors: madore c. Nat Immunol. 2023 Nov;24(11):1839-1853. doi: 10.1038/s41590-023-01627-6. Epub 2023 Sep 25. Nat Immunol. 2023. PMID: 37749326
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Yin Z, et al. Among authors: madore c. Nat Neurosci. 2023 Jul;26(7):1196-1207. doi: 10.1038/s41593-023-01355-y. Epub 2023 Jun 8. Nat Neurosci. 2023. PMID: 37291336
Microglial confetti party.
Madore C, Baufeld C, Butovsky O. Madore C, et al. Nat Neurosci. 2017 May 25;20(6):762-763. doi: 10.1038/nn.4570. Nat Neurosci. 2017. PMID: 28542157 Free PMC article.
Microglia, Lifestyle Stress, and Neurodegeneration.
Madore C, Yin Z, Leibowitz J, Butovsky O. Madore C, et al. Immunity. 2020 Feb 18;52(2):222-240. doi: 10.1016/j.immuni.2019.12.003. Epub 2020 Jan 7. Immunity. 2020. PMID: 31924476 Free PMC article. Review.
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM. Wang C, et al. Among authors: madore c. Neuron. 2021 May 19;109(10):1657-1674.e7. doi: 10.1016/j.neuron.2021.03.024. Epub 2021 Apr 7. Neuron. 2021. PMID: 33831349 Free PMC article.
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.
Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O. Margeta MA, et al. Among authors: madore c. Immunity. 2022 Sep 13;55(9):1627-1644.e7. doi: 10.1016/j.immuni.2022.07.014. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977543 Free PMC article.
TREMendous 2 Be Social.
Calcagno N, Baufeld C, Madore C, Butovsky O. Calcagno N, et al. Among authors: madore c. Immunity. 2018 May 15;48(5):842-843. doi: 10.1016/j.immuni.2018.04.034. Immunity. 2018. PMID: 29768169 Free PMC article.
Microglial Phenotypes and Functions in Multiple Sclerosis.
O'Loughlin E, Madore C, Lassmann H, Butovsky O. O'Loughlin E, et al. Among authors: madore c. Cold Spring Harb Perspect Med. 2018 Feb 1;8(2):a028993. doi: 10.1101/cshperspect.a028993. Cold Spring Harb Perspect Med. 2018. PMID: 29419406 Free PMC article. Review.
37 results