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The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinocytes.
Madonna S, Scarponi C, Sestito R, Pallotta S, Cavani A, Albanesi C. Madonna S, et al. J Immunol. 2010 Aug 15;185(4):2467-81. doi: 10.4049/jimmunol.1001426. Epub 2010 Jul 19. J Immunol. 2010. PMID: 20644166
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