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Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
Castro J, Harrington AM, Lieu T, Garcia-Caraballo S, Maddern J, Schober G, O'Donnell T, Grundy L, Lumsden AL, Miller P, Ghetti A, Steinhoff MS, Poole DP, Dong X, Chang L, Bunnett NW, Brierley SM. Castro J, et al. Among authors: maddern j. JCI Insight. 2019 Oct 17;4(20):e131712. doi: 10.1172/jci.insight.131712. JCI Insight. 2019. PMID: 31536477 Free PMC article.
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.
Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, Vetter I. Inserra MC, et al. Among authors: maddern j. Sci Rep. 2017 Feb 22;7:42810. doi: 10.1038/srep42810. Sci Rep. 2017. PMID: 28225079 Free PMC article.
Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain.
Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Castro J, et al. Among authors: maddern j. Br J Pharmacol. 2018 Jun;175(12):2384-2398. doi: 10.1111/bph.14115. Epub 2018 Feb 13. Br J Pharmacol. 2018. PMID: 29194563 Free PMC article.
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
Grundy L, Harrington AM, Castro J, Garcia-Caraballo S, Deiteren A, Maddern J, Rychkov GY, Ge P, Peters S, Feil R, Miller P, Ghetti A, Hannig G, Kurtz CB, Silos-Santiago I, Brierley SM. Grundy L, et al. Among authors: maddern j. JCI Insight. 2018 Oct 4;3(19):e121841. doi: 10.1172/jci.insight.121841. JCI Insight. 2018. PMID: 30282832 Free PMC article.
Pain in Endometriosis.
Maddern J, Grundy L, Castro J, Brierley SM. Maddern J, et al. Front Cell Neurosci. 2020 Oct 6;14:590823. doi: 10.3389/fncel.2020.590823. eCollection 2020. Front Cell Neurosci. 2020. PMID: 33132854 Free PMC article. Review.
Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents.
Castro J, Garcia-Caraballo S, Maddern J, Schober G, Lumsden A, Harrington A, Schmiel S, Lindstrom B, Adams J, Brierley SM. Castro J, et al. Among authors: maddern j. Pain. 2022 Jan 1;163(1):e72-e86. doi: 10.1097/j.pain.0000000000002314. Pain. 2022. PMID: 33863856 Free PMC article.
29 results