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Disease diagnostics using machine learning of immune receptors.
Zaslavsky ME, Craig E, Michuda JK, Sehgal N, Ram-Mohan N, Lee JY, Nguyen KD, Hoh RA, Pham TD, Röltgen K, Lam B, Parsons ES, Macwana SR, DeJager W, Drapeau EM, Roskin KM, Cunningham-Rundles C, Moody MA, Haynes BF, Goldman JD, Heath JR, Nadeau KC, Pinsky BA, Blish CA, Hensley SE, Jensen K, Meyer E, Balboni I, Utz PJ, Merrill JT, Guthridge JM, James JA, Yang S, Tibshirani R, Kundaje A, Boyd SD. Zaslavsky ME, et al. Among authors: macwana sr. bioRxiv [Preprint]. 2024 Apr 3:2022.04.26.489314. doi: 10.1101/2022.04.26.489314. bioRxiv. 2024. PMID: 35547855 Free PMC article. Preprint.
Serologic markers of Epstein-Barr virus reactivation are associated with increased disease activity, inflammation, and interferon pathway activation in patients with systemic lupus erythematosus.
Wood RA, Guthridge L, Thurmond E, Guthridge CJ, Kheir JM, Bourn RL, Wagner CA, Chen H, DeJager W, Macwana SR, Kamp S, Lu R, Arriens C, Chakravarty EF, Thanou A, Merrill JT, Guthridge JM, James JA. Wood RA, et al. Among authors: macwana sr. J Transl Autoimmun. 2021 Aug 31;4:100117. doi: 10.1016/j.jtauto.2021.100117. eCollection 2021. J Transl Autoimmun. 2021. PMID: 35005588 Free PMC article.
Adults with systemic lupus exhibit distinct molecular phenotypes in a cross-sectional study.
Guthridge JM, Lu R, Tran LT, Arriens C, Aberle T, Kamp S, Munroe ME, Dominguez N, Gross T, DeJager W, Macwana SR, Bourn RL, Apel S, Thanou A, Chen H, Chakravarty EF, Merrill JT, James JA. Guthridge JM, et al. Among authors: macwana sr. EClinicalMedicine. 2020 Mar 4;20:100291. doi: 10.1016/j.eclinm.2020.100291. eCollection 2020 Mar. EClinicalMedicine. 2020. PMID: 32154507 Free PMC article.
Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.
Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Guthridge JM, et al. Among authors: macwana sr. Am J Hum Genet. 2014 Apr 3;94(4):586-98. doi: 10.1016/j.ajhg.2014.03.008. Am J Hum Genet. 2014. PMID: 24702955 Free PMC article.
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus.
Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC, Dedeke AB, Harley JB, Scofield RH, Guthridge JM, James JA. Ritterhouse LL, et al. Among authors: macwana sr. Ann Rheum Dis. 2011 Sep;70(9):1569-74. doi: 10.1136/ard.2010.148494. Epub 2011 May 17. Ann Rheum Dis. 2011. PMID: 21586442 Free PMC article.
Genetic associations of LYN with systemic lupus erythematosus.
Lu R, Vidal GS, Kelly JA, Delgado-Vega AM, Howard XK, Macwana SR, Dominguez N, Klein W, Burrell C, Harley IT, Kaufman KM, Bruner GR, Moser KL, Gaffney PM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Divers J, Alarcón GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G Jr, Vilá LM, Petri MA, Bae SC, Cho SK, Bang SY, Kim I, Choi CB, Martin J, Vyse TJ, Merrill JT, Harley JB, Alarcón-Riquelme ME; BIOLUPUS and GENLES Multicenter Collaborations; Nath SK, James JA, Guthridge JM. Lu R, et al. Among authors: macwana sr. Genes Immun. 2009 Jul;10(5):397-403. doi: 10.1038/gene.2009.19. Epub 2009 Apr 16. Genes Immun. 2009. PMID: 19369946 Free PMC article.