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Galectin-3: therapeutic targeting in liver disease.
Mackinnon AC, Tonev D, Jacoby B, Pinzani M, Slack RJ. Mackinnon AC, et al. Expert Opin Ther Targets. 2023 Jul-Dec;27(9):779-791. doi: 10.1080/14728222.2023.2258280. Epub 2023 Sep 15. Expert Opin Ther Targets. 2023. PMID: 37705214 Review.
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants.
Aslanis V, Slack RJ, MacKinnon AC, McClinton C, Tantawi S, Gravelle L, Nilsson UJ, Leffler H, Brooks A, Khindri SK, Marshall RP, Pedersen A, Schambye H, Zetterberg F. Aslanis V, et al. Among authors: mackinnon ac. Cancer Chemother Pharmacol. 2023 Mar;91(3):267-280. doi: 10.1007/s00280-023-04513-y. Epub 2023 Mar 13. Cancer Chemother Pharmacol. 2023. PMID: 36914828 Free PMC article. Clinical Trial.
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.
Mabbitt J, Holyer ID, Roper JA, Nilsson UJ, Zetterberg FR, Vuong L, Mackinnon AC, Pedersen A, Slack RJ. Mabbitt J, et al. Among authors: mackinnon ac. Front Immunol. 2023 Aug 28;14:1250559. doi: 10.3389/fimmu.2023.1250559. eCollection 2023. Front Immunol. 2023. PMID: 37701441 Free PMC article.
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
Calver JF, Parmar NR, Harris G, Lithgo RM, Stylianou P, Zetterberg FR, Gooptu B, Mackinnon AC, Carr SB, Borthwick LA, Scott DJ, Stewart ID, Slack RJ, Jenkins RG, John AE. Calver JF, et al. Among authors: mackinnon ac. J Biol Chem. 2024 Apr 17:107300. doi: 10.1016/j.jbc.2024.107300. Online ahead of print. J Biol Chem. 2024. PMID: 38641066 Free article.
In Reply.
Mackinnon AC Jr, Harada S. Mackinnon AC Jr, et al. Arch Pathol Lab Med. 2024 May 1;148(5):507. doi: 10.5858/arpa.2024-0067-LE. Arch Pathol Lab Med. 2024. PMID: 38662905 Free article. No abstract available.
Molecular Characterization of Juxtaglomerular Cell Tumors: Evidence of Alterations in MAPK-RAS Pathway.
Lobo J, Canete-Portillo S, Pena MDCR, McKenney JK, Aron M, Massicano F, Wilk BM, Gajapathy M, Brown DM, Baydar DE, Matoso A, Rioux-Leclerq N, Pan CC, Tretiakova MS, Trpkov K, Williamson SR, Rais-Bahrami S, Mackinnon AC, Harada S, Worthey EA, Magi-Galluzzi C. Lobo J, et al. Among authors: mackinnon ac. Mod Pathol. 2024 Apr 16;37(6):100492. doi: 10.1016/j.modpat.2024.100492. Online ahead of print. Mod Pathol. 2024. PMID: 38614322
138 results