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Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.
Felizardo RJF, de Almeida DC, Pereira RL, Watanabe IKM, Doimo NTS, Ribeiro WR, Cenedeze MA, Hiyane MI, Amano MT, Braga TT, Ferreira CM, Parmigiani RB, Andrade-Oliveira V, Volpini RA, Vinolo MAR, Mariño E, Robert R, Mackay CR, Camara NOS. Felizardo RJF, et al. Among authors: mackay cr. FASEB J. 2019 Nov;33(11):11894-11908. doi: 10.1096/fj.201901080R. Epub 2019 Jul 31. FASEB J. 2019. PMID: 31366236
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR. Macia L, et al. Among authors: mackay cr. Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734. Nat Commun. 2015. PMID: 25828455 Free article.
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.
Thorburn AN, McKenzie CI, Shen S, Stanley D, Macia L, Mason LJ, Roberts LK, Wong CH, Shim R, Robert R, Chevalier N, Tan JK, Mariño E, Moore RJ, Wong L, McConville MJ, Tull DL, Wood LG, Murphy VE, Mattes J, Gibson PG, Mackay CR. Thorburn AN, et al. Among authors: mackay cr. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320. Nat Commun. 2015. PMID: 26102221 Free article.
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.
Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR. Mariño E, et al. Among authors: mackay cr. Nat Immunol. 2017 May;18(5):552-562. doi: 10.1038/ni.3713. Epub 2017 Mar 27. Nat Immunol. 2017. PMID: 28346408
249 results