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SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI); Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE. Wendisch D, et al. Among authors: mache c. Cell. 2021 Dec 22;184(26):6243-6261.e27. doi: 10.1016/j.cell.2021.11.033. Epub 2021 Nov 27. Cell. 2021. PMID: 34914922 Free PMC article.
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C. Schroeder S, et al. Among authors: mache c. Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. Nat Commun. 2021. PMID: 34493730 Free PMC article.
Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses.
Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T. Schulze J, et al. Among authors: mache c. J Infect Dis. 2021 Dec 15;224(12):2020-2024. doi: 10.1093/infdis/jiab523. J Infect Dis. 2021. PMID: 34651643 Free PMC article.
Deep Time Course Proteomics of SARS-CoV- and SARS-CoV-2-Infected Human Lung Epithelial Cells (Calu-3) Reveals Strong Induction of Interferon-Stimulated Gene Expression by SARS-CoV-2 in Contrast to SARS-CoV.
Grossegesse M, Bourquain D, Neumann M, Schaade L, Schulze J, Mache C, Wolff T, Nitsche A, Doellinger J. Grossegesse M, et al. Among authors: mache c. J Proteome Res. 2022 Feb 4;21(2):459-469. doi: 10.1021/acs.jproteome.1c00783. Epub 2022 Jan 4. J Proteome Res. 2022. PMID: 34982558
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fatykhova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Hönzke K, et al. Among authors: mache c. Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35728978 Free PMC article.
SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C. Niemeyer D, et al. Among authors: mache c. PLoS Biol. 2022 Nov 16;20(11):e3001871. doi: 10.1371/journal.pbio.3001871. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36383605 Free PMC article.
Bat-borne H9N2 influenza virus evades MxA restriction and exhibits efficient replication and transmission in ferrets.
Halwe NJ, Hamberger L, Sehl-Ewert J, Mache C, Schön J, Ulrich L, Calvelage S, Tönnies M, Fuchs J, Bandawane P, Loganathan M, Abbad A, Carreño JM, Bermúdez-González MC, Simon V, Kandeil A, El-Shesheny R, Ali MA, Kayali G, Budt M, Hippenstiel S, Hocke AC, Krammer F, Wolff T, Schwemmle M, Ciminski K, Hoffmann D, Beer M. Halwe NJ, et al. Among authors: mache c. Nat Commun. 2024 Apr 25;15(1):3450. doi: 10.1038/s41467-024-47455-6. Nat Commun. 2024. PMID: 38664395 Free PMC article.
Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome.
Fu Y, Wedde M, Smola S, Oh DY, Pfuhl T, Rissland J, Zemlin M, Flockerzi FA, Bohle RM, Thürmer A, Duwe S, Biere B, Reiche J, Schweiger B, Mache C, Wolff T, Herrler G, Dürrwald R. Fu Y, et al. Among authors: mache c. Int J Med Microbiol. 2024 Mar;314:151598. doi: 10.1016/j.ijmm.2024.151598. Epub 2024 Jan 11. Int J Med Microbiol. 2024. PMID: 38237287 Free article.
86 results