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Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Alivernini S, MacDonald L, Elmesmari A, Finlay S, Tolusso B, Gigante MR, Petricca L, Di Mario C, Bui L, Perniola S, Attar M, Gessi M, Fedele AL, Chilaka S, Somma D, Sansom SN, Filer A, McSharry C, Millar NL, Kirschner K, Nerviani A, Lewis MJ, Pitzalis C, Clark AR, Ferraccioli G, Udalova I, Buckley CD, Gremese E, McInnes IB, Otto TD, Kurowska-Stolarska M. Alivernini S, et al. Among authors: macdonald l. Nat Med. 2020 Aug;26(8):1295-1306. doi: 10.1038/s41591-020-0939-8. Epub 2020 Jun 29. Nat Med. 2020. PMID: 32601335
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes.
MacDonald L, Alivernini S, Tolusso B, Elmesmari A, Somma D, Perniola S, Paglionico A, Petricca L, Bosello SL, Carfì A, Sali M, Stigliano E, Cingolani A, Murri R, Arena V, Fantoni M, Antonelli M, Landi F, Franceschi F, Sanguinetti M, McInnes IB, McSharry C, Gasbarrini A, Otto TD, Kurowska-Stolarska M, Gremese E. MacDonald L, et al. JCI Insight. 2021 Jun 18;6(13):e147413. doi: 10.1172/jci.insight.147413. JCI Insight. 2021. PMID: 34143756 Free PMC article.
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48.
Clayton SA, Daley KK, MacDonald L, Fernandez-Vizarra E, Bottegoni G, O'Neil JD, Major T, Griffin D, Zhuang Q, Adewoye AB, Woolcock K, Jones SW, Goodyear C, Elmesmari A, Filer A, Tennant DA, Alivernini S, Buckley CD, Pitceathly RDS, Kurowska-Stolarska M, Clark AR. Clayton SA, et al. Among authors: macdonald l. Sci Adv. 2021 Dec 10;7(50):eabl5182. doi: 10.1126/sciadv.abl5182. Epub 2021 Dec 8. Sci Adv. 2021. PMID: 34878835 Free PMC article.
Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis.
Micheroli R, Elhai M, Edalat S, Frank-Bertoncelj M, Bürki K, Ciurea A, MacDonald L, Kurowska-Stolarska M, Lewis MJ, Goldmann K, Cubuk C, Kuret T, Distler O, Pitzalis C, Ospelt C. Micheroli R, et al. Among authors: macdonald l. RMD Open. 2022 Jan;8(1):e001949. doi: 10.1136/rmdopen-2021-001949. RMD Open. 2022. PMID: 34987094 Free PMC article.
miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation.
Olsson AM, Povoleri GAM, Somma D, Ridley ML, Rizou T, Lalnunhlimi S, Macdonald L, Rajasekhar M, Martinez-Nunez RT, Kurowska-Stolarska M, Taams LS. Olsson AM, et al. Among authors: macdonald l. Clin Exp Immunol. 2022 Apr 4;207(2):188-198. doi: 10.1093/cei/uxab016. Clin Exp Immunol. 2022. PMID: 35020867 Free PMC article.
Pro Nerve Growth Factor and Its Receptor p75NTR Activate Inflammatory Responses in Synovial Fibroblasts: A Novel Targetable Mechanism in Arthritis.
Farina L, Minnone G, Alivernini S, Caiello I, MacDonald L, Soligo M, Manni L, Tolusso B, Coppola S, Zara E, Conti LA, Aquilani A, Magni-Manzoni S, Kurowska-Stolarska M, Gremese E, De Benedetti F, Bracci-Laudiero L. Farina L, et al. Among authors: macdonald l. Front Immunol. 2022 Mar 4;13:818630. doi: 10.3389/fimmu.2022.818630. eCollection 2022. Front Immunol. 2022. PMID: 35309353 Free PMC article.
738 results