Macías-González M - Search Results

1

Discovery of Potent Dual PPARα Agonists/CB1 Ligands.

Pérez-Fernández R, Fresno N, Macías-González M, Elguero J, Decara J, Girón R, Rodríguez-Álvarez A, Martín MI, Rodríguez de Fonseca F, Goya P. Pérez-Fernández R, et al. ACS Med Chem Lett. 2011 Sep 16;2(11):793-7. doi: 10.1021/ml200091q. eCollection 2011 Nov 10. ACS Med Chem Lett. 2011. PMID: 24936232 Free PMC article.

2

Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.

Cano C, Pavón J, Serrano A, Goya P, Paez JA, de Fonseca FR, Macias-Gonzalez M. Cano C, et al. J Med Chem. 2007 Jan 25;50(2):389-93. doi: 10.1021/jm0601102. J Med Chem. 2007. PMID: 17228882

3

Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

Alvarado M, Goya P, Macías-González M, Pavón FJ, Serrano A, Jagerovic N, Elguero J, Gutiérrez-Rodríguez A, García-Granda S, Suardíaz M, Rodríguez de Fonseca F. Alvarado M, et al. Bioorg Med Chem. 2008 Dec 1;16(23):10098-105. doi: 10.1016/j.bmc.2008.10.023. Epub 2008 Oct 14. Bioorg Med Chem. 2008. PMID: 18952442

4

Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties.

Almeida B, Joglar J, Luque Rojas MJ, Decara JM, Bermúdez-Silva FJ, Macias-González M, Fitó M, Romero-Cuevas M, Farré M, Covas MI, Rodríguez de Fonseca F, de la Torre R. Almeida B, et al. ChemMedChem. 2010 Oct 4;5(10):1781-7. doi: 10.1002/cmdc.201000161. ChemMedChem. 2010. PMID: 20718074

5

Anti-obesity efficacy of LH-21, a cannabinoid CB(1) receptor antagonist with poor brain penetration, in diet-induced obese rats.

Alonso M, Serrano A, Vida M, Crespillo A, Hernandez-Folgado L, Jagerovic N, Goya P, Reyes-Cabello C, Perez-Valero V, Decara J, Macías-González M, Bermúdez-Silva FJ, Suárez J, Rodríguez de Fonseca F, Pavón FJ. Alonso M, et al. Br J Pharmacol. 2012 Apr;165(7):2274-91. doi: 10.1111/j.1476-5381.2011.01698.x. Br J Pharmacol. 2012. PMID: 21951309 Free PMC article.

6

Elaidyl-sulfamide, an oleoylethanolamide-modelled PPARα agonist, reduces body weight gain and plasma cholesterol in rats.

Decara JM, Romero-Cuevas M, Rivera P, Macias-González M, Vida M, Pavón FJ, Serrano A, Cano C, Fresno N, Pérez-Fernández R, Rodríguez de Fonseca F, Suárez J. Decara JM, et al. Dis Model Mech. 2012 Sep;5(5):660-70. doi: 10.1242/dmm.009233. Epub 2012 Jun 26. Dis Model Mech. 2012. PMID: 22736460 Free PMC article.

7

Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPARα agonist structurally related to N-acylethanolamines.

Moreno-Santos I, Pavón FJ, Romero-Cuevas M, Serrano A, Cano C, Suardíaz M, Decara J, Suarez J, de Fonseca FR, Macías-González M. Moreno-Santos I, et al. PLoS One. 2014 Mar 20;9(3):e92195. doi: 10.1371/journal.pone.0092195. eCollection 2014. PLoS One. 2014. PMID: 24651609 Free PMC article.

8

Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.

Fresno N, Macías-González M, Torres-Zaguirre A, Romero-Cuevas M, Sanz-Camacho P, Elguero J, Pavón FJ, Rodríguez de Fonseca F, Goya P, Pérez-Fernández R. Fresno N, et al. J Med Chem. 2015 Aug 27;58(16):6639-52. doi: 10.1021/acs.jmedchem.5b00849. Epub 2015 Aug 12. J Med Chem. 2015. PMID: 26226490 Free article.

9

Molecular effect of fenofibrate on PBMC gene transcription related to lipid metabolism in patients with metabolic syndrome.

Moreno-Indias I, Tinahones FJ, Clemente-Postigo M, Castellano-Castillo D, Fernández-García JC, Macias-Gonzalez M, Queipo-Ortuño MI, Cardona F. Moreno-Indias I, et al. Clin Endocrinol (Oxf). 2017 Jun;86(6):784-790. doi: 10.1111/cen.13320. Epub 2017 Mar 27. Clin Endocrinol (Oxf). 2017. PMID: 28251701

10

Pro12Ala sequence variant of the PPARG gene is associated with postprandial hypertriglyceridemia in non-E3/E3 patients with the metabolic syndrome.

Cardona F, Morcillo S, Gonzalo-Marín M, Garrido-Sanchez L, Macias-Gonzalez M, Tinahones FJ. Cardona F, et al. Clin Chem. 2006 Oct;52(10):1920-5. doi: 10.1373/clinchem.2006.069690. Epub 2006 Aug 17. Clin Chem. 2006. PMID: 16916989

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