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Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Pérez PS, Robles JMR, Bermúdez-Jiménez FJ, Díaz-Agustín A, de Benito FM, Santiago SA, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: macias a. bioRxiv [Preprint]. 2023 Jun 8:2023.06.07.544151. doi: 10.1101/2023.06.07.544151. bioRxiv. 2023. PMID: 37333254 Free PMC article. Preprint.
Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson-Gilford progeria syndrome.
Macías Á, Díaz-Larrosa JJ, Blanco Y, Fanjul V, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, da Rocha AM, Ponce-Balbuena D, Allan A, Filgueiras-Rama D, Jalife J, Andrés V. Macías Á, et al. Cardiovasc Res. 2022 Jan 29;118(2):503-516. doi: 10.1093/cvr/cvab055. Cardiovasc Res. 2022. PMID: 33624748 Free PMC article.
SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients.
Jimenez-Vazquez EN, Arad M, Macías Á, Vera-Pedrosa ML, Cruz FM, Gutierrez LK, Cuttitta AJ, Monteiro da Rocha A, Herron TJ, Ponce-Balbuena D, Guerrero-Serna G, Binah O, Michele DE, Jalife J. Jimenez-Vazquez EN, et al. Among authors: macias a. Elife. 2022 Jun 28;11:e76576. doi: 10.7554/eLife.76576. Elife. 2022. PMID: 35762211 Free PMC article.
Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil syndrome.
Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Cruz FM, Bermúdez-Jiménez FJ, Martínez-Carrascoso I, Sánchez-Pérez P, Macías Á, Jalife J. Moreno-Manuel AI, et al. Among authors: macias a. Cardiovasc Res. 2023 May 2;119(4):919-932. doi: 10.1093/cvr/cvac118. Cardiovasc Res. 2023. PMID: 35892314 Free PMC article.
The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3.
Moreno-Manuel AI, Macías Á, Cruz FM, Gutiérrez LK, Martínez F, González-Guerra A, Martínez Carrascoso I, Bermúdez-Jimenez FJ, Sánchez-Pérez P, Vera-Pedrosa ML, Ruiz-Robles JM, Bernal JA, Jalife J. Moreno-Manuel AI, et al. Among authors: macias a. Cardiovasc Res. 2024 Apr 30;120(5):490-505. doi: 10.1093/cvr/cvae019. Cardiovasc Res. 2024. PMID: 38261726 Free PMC article.
Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Sánchez Pérez P, Ruiz Robles JM, Bermúdez-Jiménez FJ, Díaz-Agustín A, Martínez de Benito F, Arias-Santiago S, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: macias a. Circ Res. 2024 Apr 12;134(8):e52-e71. doi: 10.1161/CIRCRESAHA.123.323895. Epub 2024 Mar 18. Circ Res. 2024. PMID: 38497220 Free article.
KV1.5-KVβ1.3 Recycling Is PKC-Dependent.
Macias A, de la Cruz A, Peraza DA, Benito-Bueno A, Gonzalez T, Valenzuela C. Macias A, et al. Int J Mol Sci. 2021 Jan 29;22(3):1336. doi: 10.3390/ijms22031336. Int J Mol Sci. 2021. PMID: 33572906 Free PMC article.
Polyunsaturated Fatty acids modify the gating of kv channels.
Moreno C, Macias A, Prieto A, De La Cruz A, Valenzuela C. Moreno C, et al. Among authors: macias a. Front Pharmacol. 2012 Sep 10;3:163. doi: 10.3389/fphar.2012.00163. eCollection 2012. Front Pharmacol. 2012. PMID: 22973228 Free PMC article.
428 results