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2017 2
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2024 0

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Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
VanDyke D, Iglesias M, Tomala J, Young A, Smith J, Perry JA, Gebara E, Cross AR, Cheung LS, Dykema AG, Orcutt-Jahns BT, Henclová T, Golias J, Balolong J, Tomasovic LM, Funda D, Meyer AS, Pardoll DM, Hester J, Issa F, Hunter CA, Anderson MS, Bluestone JA, Raimondi G, Spangler JB. VanDyke D, et al. Cell Rep. 2022 Oct 18;41(3):111478. doi: 10.1016/j.celrep.2022.111478. Cell Rep. 2022. PMID: 36261022 Free PMC article.
Regulatory T-cell therapy approaches.
McCallion O, Bilici M, Hester J, Issa F. McCallion O, et al. Clin Exp Immunol. 2023 Mar 16;211(2):96-107. doi: 10.1093/cei/uxac078. Clin Exp Immunol. 2023. PMID: 35960852 Free PMC article. Review.
Editorial: Regulatory T Cells.
Issa F, Gu J, Lu L. Issa F, et al. Front Cell Dev Biol. 2022 Apr 21;10:898132. doi: 10.3389/fcell.2022.898132. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35531095 Free PMC article. No abstract available.
Transplantation Without Overimmunosuppression (TWO) study protocol: a phase 2b randomised controlled single-centre trial of regulatory T cell therapy to facilitate immunosuppression reduction in living donor kidney transplant recipients.
Brook MO, Hester J, Petchey W, Rombach I, Dutton S, Bottomley MJ, Black J, Abdul-Wahab S, Bushell A, Lombardi G, Wood K, Friend P, Harden P, Issa F. Brook MO, et al. BMJ Open. 2022 Apr 15;12(4):e061864. doi: 10.1136/bmjopen-2022-061864. BMJ Open. 2022. PMID: 35428650 Free PMC article.
Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo.
Kaiser D, Otto NM, McCallion O, Hoffmann H, Zarrinrad G, Stein M, Beier C, Matz I, Herschel M, Hester J, Moll G, Issa F, Reinke P, Roemhild A. Kaiser D, et al. Front Cell Dev Biol. 2021 Dec 3;9:750286. doi: 10.3389/fcell.2021.750286. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34926446 Free PMC article.
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Jarvis LB, Rainbow DB, Coppard V, Howlett SK, Georgieva Z, Davies JL, Mullay HK, Hester J, Ashmore T, Van Den Bosch A, Grist JT, Coles AJ, Mousa HS, Pluchino S, Mahbubani KT, Griffin JL, Saeb-Parsy K, Issa F, Peruzzotti-Jametti L, Wicker LS, Jones JL. Jarvis LB, et al. Commun Biol. 2021 Oct 14;4(1):1186. doi: 10.1038/s42003-021-02721-x. Commun Biol. 2021. PMID: 34650224 Free PMC article.
24 results