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Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Methyl Metabolism and in Sex-Specific Placental Transcription Changes.
Mol Nutr Food Res. 2021 Jul;65(14):e2100197. doi: 10.1002/mnfr.202100197. Epub 2021 Jun 10.
Mol Nutr Food Res. 2021.
PMID: 34010503
High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis.
Leclerc D, Jelinek J, Christensen KE, Issa JJ, Rozen R.
Leclerc D, et al.
J Nutr Biochem. 2021 Feb;88:108554. doi: 10.1016/j.jnutbio.2020.108554. Epub 2020 Nov 19.
J Nutr Biochem. 2021.
PMID: 33220403
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Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.
Leclerc D, Christensen KE, Cauvi O, Yang E, Fournelle F, Bahous RH, Malysheva OV, Deng L, Wu Q, Zhou Z, Gao ZH, Chaurand P, Caudill MA, Rozen R.
Leclerc D, et al.
Mol Nutr Food Res. 2019 Feb;63(3):e1801001. doi: 10.1002/mnfr.201801001. Epub 2018 Nov 23.
Mol Nutr Food Res. 2019.
PMID: 30408316
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High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Bahous RH, Jadavji NM, Deng L, Cosín-Tomás M, Lu J, Malysheva O, Leung KY, Ho MK, Pallàs M, Kaliman P, Greene NDE, Bedell BJ, Caudill MA, Rozen R.
Bahous RH, et al.
Hum Mol Genet. 2017 Mar 1;26(5):888-900. doi: 10.1093/hmg/ddx004.
Hum Mol Genet. 2017.
PMID: 28069796
Free PMC article.
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