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2023 3
2024 8

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Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson's disease.
Mancini M, Calculli A, Di Martino D, Pisani A. Mancini M, et al. J Anesth Analg Crit Care. 2024 May 14;4(1):33. doi: 10.1186/s44158-024-00169-z. J Anesth Analg Crit Care. 2024. PMID: 38745258 Review.
However, eCBs play an even more intricate and intimate relationship with DA, as indicated by the adaptive changes in the eCB system following DA depletion. Although the precise mechanisms underlying DA control on pain are not fully understood, given the high correlation of …
However, eCBs play an even more intricate and intimate relationship with DA, as indicated by the adaptive changes in the eCB system f …
Two Signaling Modes Are Better than One: Flux-Independent Signaling by Ionotropic Glutamate Receptors Is Coming of Age.
Brunetti V, Soda T, Berra-Romani R, De Sarro G, Guerra G, Scarpellino G, Moccia F. Brunetti V, et al. Biomedicines. 2024 Apr 16;12(4):880. doi: 10.3390/biomedicines12040880. Biomedicines. 2024. PMID: 38672234 Free PMC article. Review.
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs), which mediate rapid synaptic depolarization that can be associated with Ca(2+) entry and activity …
Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated b …
Involvement of the claustrum in the cortico-basal ganglia circuitry: connectional study in the non-human primate.
Borra E, Ballestrazzi G, Biancheri D, Caminiti R, Luppino G. Borra E, et al. Brain Struct Funct. 2024 Apr 14. doi: 10.1007/s00429-024-02784-6. Online ahead of print. Brain Struct Funct. 2024. PMID: 38615290
This structure has a general role in modulating cortical excitability and is considered to be engaged in different cognitive and motor functions, such as sensory integration and perceptual binding, salience-guided attention, top-down executive functions, as well as in the control …
This structure has a general role in modulating cortical excitability and is considered to be engaged in different cognitive and motor funct …
Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging.
Guglielmi V, Cheli M, Tonin P, Vattemi G. Guglielmi V, et al. Int J Mol Sci. 2024 Feb 27;25(5):2742. doi: 10.3390/ijms25052742. Int J Mol Sci. 2024. PMID: 38473988 Free PMC article. Review.
At present, there are no enduring treatments for this relentless disease that eventually leads to severe disability and wheelchair dependency. ...Here, we outline our current understanding of disease pathogenesis, focusing on degenerative mechanisms, and discuss the …
At present, there are no enduring treatments for this relentless disease that eventually leads to severe disability and wheelchair de …
Functional Study of SNCA p.V15A Variant: Further Linking alpha-Synuclein and Glucocerebrosidase.
Avenali M, Cerri S, Palmieri I, Ongari G, Stiuso R, Buongarzone G, Tassorelli C, Biagini T, Valente M, Cereda C, Mazza T, Gana S, Pacchetti C, Valente EM. Avenali M, et al. Mov Disord. 2024 Mar 4. doi: 10.1002/mds.29736. Online ahead of print. Mov Disord. 2024. PMID: 38436488
OBJECTIVES: To clinically and functionally evaluate SNCA p.V15A in a large Italian family with Parkinson's disease (PD). METHODS: Genetic diagnosis was reached through next-generation sequencing. ...Proband's PBMCs showed elevated total and phosphorylated alpha-synuclein ( …
OBJECTIVES: To clinically and functionally evaluate SNCA p.V15A in a large Italian family with Parkinson's disease (PD). METHODS: Gen …
Neutrophil degranulation, endothelial and metabolic dysfunction in unvaccinated long COVID patients.
Di Ciaula A, Liberale L, Portincasa P, Khalil M, Galerati I, Farella I, Noto A, JohnBritto S, Moriero M, Michelauz C, Frè F, Olivero C, Bertolotto M, Montecucco F, Carbone F, Bonfrate L. Di Ciaula A, et al. Eur J Clin Invest. 2024 Apr;54(4):e14155. doi: 10.1111/eci.14155. Epub 2024 Jan 16. Eur J Clin Invest. 2024. PMID: 38226472
BACKGROUND: Long COVID symptoms are widely diffused and have a poorly understood pathophysiology, with possible involvement of inflammatory cytokines. MATERIALS AND METHODS: A prospective follow-up study involved 385 unvaccinated patients, started 1 month after SARS-CoV-2 …
BACKGROUND: Long COVID symptoms are widely diffused and have a poorly understood pathophysiology, with possible involvement of inflammatory …
Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study.
Straudi S, Antonioni A, Baroni A, Bonsangue V, Lavezzi S, Koch G, Tisato V, Ziliotto N, Basaglia N, Secchiero P, Manfredini F, Lamberti N. Straudi S, et al. J Clin Med. 2023 Dec 24;13(1):108. doi: 10.3390/jcm13010108. J Clin Med. 2023. PMID: 38202115 Free PMC article.
Disorders of consciousness (DoC) due to severe traumatic brain injury (TBI) are associated with severe disability and an alteration of cortical activation, angiogenesis, and inflammation, which are crucial elements for behavioural recovery. This exploratory study aimed to …
Disorders of consciousness (DoC) due to severe traumatic brain injury (TBI) are associated with severe disability and an alteration of corti …
Cracking the Endothelial Calcium (Ca2+) Code: A Matter of Timing and Spacing.
Moccia F, Brunetti V, Soda T, Berra-Romani R, Scarpellino G. Moccia F, et al. Int J Mol Sci. 2023 Nov 26;24(23):16765. doi: 10.3390/ijms242316765. Int J Mol Sci. 2023. PMID: 38069089 Free PMC article. Review.
We then illustrate how local endothelial Ca(2+) signals affect the most appropriate vascular function and are integrated to transmit this information to more distant sites to maintain cardiovascular homeostasis. ...
We then illustrate how local endothelial Ca(2+) signals affect the most appropriate vascular function and are integrated to transmit …
11 results