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Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A. Azzu V, et al. Mol Metab. 2021 Jun;48:101210. doi: 10.1016/j.molmet.2021.101210. Epub 2021 Mar 17. Mol Metab. 2021. PMID: 33722690 Free PMC article.
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Vacca M, et al. Nat Metab. 2020 Jun;2(6):514-531. doi: 10.1038/s42255-020-0214-9. Epub 2020 Jun 8. Nat Metab. 2020. PMID: 32694734
Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Hall Z, et al. Hepatology. 2021 Mar;73(3):1028-1044. doi: 10.1002/hep.31391. Epub 2020 Nov 3. Hepatology. 2021. PMID: 32460431
Ten years of Genome Medicine.
Auffray C, Griffin JL, Khoury MJ, Lupski JR, Schwab M. Auffray C, et al. Genome Med. 2019 Feb 15;11(1):7. doi: 10.1186/s13073-019-0618-x. Genome Med. 2019. PMID: 30767786 Free PMC article. No abstract available.
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.
Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Sanders FWB, et al. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. Genome Biol. 2018. PMID: 29925420 Free PMC article.