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All-d-Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-β Precursors.
Bocharov EV, Gremer L, Urban AS, Okhrimenko IS, Volynsky PE, Nadezhdin KD, Bocharova OV, Kornilov DA, Zagryadskaya YA, Kamynina AV, Kuzmichev PK, Kutzsche J, Bolakhrif N, Müller-Schiffmann A, Dencher NA, Arseniev AS, Efremov RG, Gordeliy VI, Willbold D. Bocharov EV, et al. Among authors: muller schiffmann a. J Med Chem. 2021 Nov 25;64(22):16464-16479. doi: 10.1021/acs.jmedchem.1c00632. Epub 2021 Nov 5. J Med Chem. 2021. PMID: 34739758
Combining independent drug classes into superior, synergistically acting hybrid molecules.
Müller-Schiffmann A, März-Berberich J, Andreyeva A, Rönicke R, Bartnik D, Brener O, Kutzsche J, Horn AH, Hellmert M, Polkowska J, Gottmann K, Reymann KG, Funke SA, Nagel-Steger L, Moriscot C, Schoehn G, Sticht H, Willbold D, Schrader T, Korth C. Müller-Schiffmann A, et al. Angew Chem Int Ed Engl. 2010 Nov 8;49(46):8743-6. doi: 10.1002/anie.201004437. Angew Chem Int Ed Engl. 2010. PMID: 20922735 No abstract available.
Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.
Aileen Funke S, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AH, Müller-Schiffmann A, Korth C, Sticht H, Willbold D. Aileen Funke S, et al. ACS Chem Neurosci. 2010 Sep 15;1(9):639-48. doi: 10.1021/cn100057j. Epub 2010 Aug 2. ACS Chem Neurosci. 2010. PMID: 22778851 Free PMC article.
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein.
Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C. Yerabham ASK, et al. Among authors: muller schiffmann a. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PLoS One. 2018. PMID: 29324815 Free PMC article.
34 results