Métifiot M - Search Results

1

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: metifiot m. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7309-13. doi: 10.1016/j.bmcl.2012.10.088. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2012. PMID: 23149229 Free PMC article.

2

HIV-1 IN inhibitors: 2010 update and perspectives.

Marchand C, Maddali K, Métifiot M, Pommier Y. Marchand C, et al. Among authors: metifiot m. Curr Top Med Chem. 2009;9(11):1016-37. doi: 10.2174/156802609789630910. Curr Top Med Chem. 2009. PMID: 19747122 Free PMC article. Review.

3

Biochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravir.

Métifiot M, Maddali K, Naumova A, Zhang X, Marchand C, Pommier Y. Métifiot M, et al. Biochemistry. 2010 May 4;49(17):3715-22. doi: 10.1021/bi100130f. Biochemistry. 2010. PMID: 20334344 Free PMC article.

4

Resistance to integrase inhibitors.

Métifiot M, Marchand C, Maddali K, Pommier Y. Métifiot M, et al. Viruses. 2010 Jun 25;2(7):1347-66. doi: 10.3390/v2071347. Viruses. 2010. PMID: 20706558 Free PMC article.

5

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.

Tang J, Maddali K, Metifiot M, Sham YY, Vince R, Pommier Y, Wang Z. Tang J, et al. Among authors: metifiot m. J Med Chem. 2011 Apr 14;54(7):2282-92. doi: 10.1021/jm1014378. Epub 2011 Mar 7. J Med Chem. 2011. PMID: 21381765 Free PMC article.

6

Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: metifiot m. Bioorg Med Chem Lett. 2011 May 15;21(10):2986-90. doi: 10.1016/j.bmcl.2011.03.047. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21493066 Free PMC article.

7

Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.

Johnson BC, Métifiot M, Pommier Y, Hughes SH. Johnson BC, et al. Among authors: metifiot m. Antimicrob Agents Chemother. 2012 Jan;56(1):411-9. doi: 10.1128/AAC.05292-11. Epub 2011 Oct 28. Antimicrob Agents Chemother. 2012. PMID: 22037850 Free PMC article.

8

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

Zhao XZ, Maddali K, Metifiot M, Smith SJ, Vu BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: metifiot m. Chem Biol Drug Des. 2012 Feb;79(2):157-65. doi: 10.1111/j.1747-0285.2011.01270.x. Epub 2011 Dec 22. Chem Biol Drug Des. 2012. PMID: 22107736 Free PMC article.

9

Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase.

Métifiot M, Maddali K, Johnson BC, Hare S, Smith SJ, Zhao XZ, Marchand C, Burke TR Jr, Hughes SH, Cherepanov P, Pommier Y. Métifiot M, et al. ACS Chem Biol. 2013 Jan 18;8(1):209-17. doi: 10.1021/cb300471n. Epub 2012 Dec 24. ACS Chem Biol. 2013. PMID: 23075516 Free PMC article.

10

A homology model of HIV-1 integrase and analysis of mutations designed to test the model.

Johnson BC, Métifiot M, Ferris A, Pommier Y, Hughes SH. Johnson BC, et al. Among authors: metifiot m. J Mol Biol. 2013 Jun 26;425(12):2133-46. doi: 10.1016/j.jmb.2013.03.027. Epub 2013 Mar 27. J Mol Biol. 2013. PMID: 23542006 Free PMC article.

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