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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young KC, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S, Goldberg SA, Lee SA, Lynch KL, Kelly JD, Martin JN, Münch J, Deeks SG, Henrich TJ, Roan NR. Yin K, et al. Among authors: lynch kl. Nat Immunol. 2024 Feb;25(2):218-225. doi: 10.1038/s41590-023-01724-6. Epub 2024 Jan 11. Nat Immunol. 2024. PMID: 38212464 Free PMC article.
Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2.
Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young K, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S, Goldberg SA, Lee SA, Lynch KL, Kelly JD, Martin JN, Münch J, Deeks SG, Henrich TJ, Roan NR. Yin K, et al. Among authors: lynch kl. bioRxiv [Preprint]. 2023 Aug 4:2023.02.09.527892. doi: 10.1101/2023.02.09.527892. bioRxiv. 2023. PMID: 36798286 Free PMC article. Updated. Preprint.
A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.
Augusto DG, Murdolo LD, Chatzileontiadou DSM, Sabatino JJ Jr, Yusufali T, Peyser ND, Butcher X, Kizer K, Guthrie K, Murray VW, Pae V, Sarvadhavabhatla S, Beltran F, Gill GS, Lynch KL, Yun C, Maguire CT, Peluso MJ, Hoh R, Henrich TJ, Deeks SG, Davidson M, Lu S, Goldberg SA, Kelly JD, Martin JN, Vierra-Green CA, Spellman SR, Langton DJ, Dewar-Oldis MJ, Smith C, Barnard PJ, Lee S, Marcus GM, Olgin JE, Pletcher MJ, Maiers M, Gras S, Hollenbach JA. Augusto DG, et al. Among authors: lynch kl. Nature. 2023 Aug;620(7972):128-136. doi: 10.1038/s41586-023-06331-x. Epub 2023 Jul 19. Nature. 2023. PMID: 37468623 Free PMC article.
A common allele of HLA mediates asymptomatic SARS-CoV-2 infection.
Augusto DG, Yusufali T, Sabatino JJ Jr, Peyser ND, Murdolo LD, Butcher X, Murray V, Pae V, Sarvadhavabhatla S, Beltran F, Gill G, Lynch K, Yun C, Maguire C, Peluso MJ, Hoh R, Henrich TJ, Deeks SG, Davidson M, Lu S, Goldberg SA, Kelly JD, Martin JN, Viera-Green CA, Spellman SR, Langton DJ, Lee S, Marcus GM, Olgin JE, Pletcher MJ, Gras S, Maiers M, Hollenbach JA. Augusto DG, et al. medRxiv [Preprint]. 2022 Oct 12:2021.05.13.21257065. doi: 10.1101/2021.05.13.21257065. medRxiv. 2022. PMID: 34031661 Free PMC article. Updated. Preprint.
SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy.
Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K. Ryu JK, et al. Among authors: lynch kl. bioRxiv [Preprint]. 2021 Oct 13:2021.10.12.464152. doi: 10.1101/2021.10.12.464152. bioRxiv. 2021. PMID: 34671772 Free PMC article. Preprint.
Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS; UCSF COMET consortium; Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. van der Wijst MGP, et al. Among authors: lynch kl. bioRxiv [Preprint]. 2021 Mar 10:2021.03.09.434529. doi: 10.1101/2021.03.09.434529. bioRxiv. 2021. PMID: 33758859 Free PMC article. Preprint.
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq.
Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Mandel-Brehm C, Miao B, Sowa G, Zorn K, Chan AY, Shimizu C, Tremoulet A, Lynch K, Wilson MR, Kampe O, Dobbs K, Delmonte OM, Notarangelo LD, Burns JC, Casanova JL, Lionakis MS, Torgerson TR, Anderson MS, DeRisi JL. Vazquez SE, et al. bioRxiv [Preprint]. 2022 Mar 24:2022.03.23.485509. doi: 10.1101/2022.03.23.485509. bioRxiv. 2022. PMID: 35350199 Free PMC article. Updated. Preprint.
Exploring X: barriers to care for eosinophilic esophagitis.
Thanawala SU, Klein A, Raval K, Amaro JIF, Beveridge CA, Muir AB, Falk GW, Gonzalez-Hernandez G, Lynch KL. Thanawala SU, et al. Among authors: lynch kl. Dis Esophagus. 2024 May 14:doae043. doi: 10.1093/dote/doae043. Online ahead of print. Dis Esophagus. 2024. PMID: 38745432
177 results