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Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.
Oliveira DV, Coupland KG, Shao W, Jin S, Del Gaudio F, Wang S, Fox R, Rutten JW, Sandin J, Zetterberg H, Lundkvist J, Lesnik Oberstein SA, Lendahl U, Karlström H. Oliveira DV, et al. Among authors: lundkvist j. EMBO Mol Med. 2023 Feb 8;15(2):e16556. doi: 10.15252/emmm.202216556. Epub 2022 Dec 16. EMBO Mol Med. 2023. PMID: 36524456 Free PMC article.
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing.
Weber TA, Lundkvist J, Wanngren J, Kvartsberg H, Jin S, Larssen P, Wu D, Oliveira DV, Minta K, Brinkmalm G, Zetterberg H, Blennow K, Nordvall G, Winblad B, Portelius E, Karlström H. Weber TA, et al. Among authors: lundkvist j. J Cell Mol Med. 2022 Feb;26(3):880-892. doi: 10.1111/jcmm.17146. Epub 2021 Dec 20. J Cell Mol Med. 2022. PMID: 34931449 Free PMC article.
Endogenous APP accumulates in synapses after BACE1 inhibition.
Nigam SM, Xu S, Ackermann F, Gregory JA, Lundkvist J, Lendahl U, Brodin L. Nigam SM, et al. Among authors: lundkvist j. Neurosci Res. 2016 Aug;109:9-15. doi: 10.1016/j.neures.2016.02.002. Epub 2016 Feb 22. Neurosci Res. 2016. PMID: 26907521
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.
Georgievska B, Gustavsson S, Lundkvist J, Neelissen J, Eketjäll S, Ramberg V, Bueters T, Agerman K, Juréus A, Svensson S, Berg S, Fälting J, Lendahl U. Georgievska B, et al. Among authors: lundkvist j. J Neurochem. 2015 Feb;132(4):477-86. doi: 10.1111/jnc.12937. Epub 2014 Sep 18. J Neurochem. 2015. PMID: 25156639 Free article.
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.
Wanngren J, Lara P, Ojemalm K, Maioli S, Moradi N, Chen L, Tjernberg LO, Lundkvist J, Nilsson I, Karlström H. Wanngren J, et al. Among authors: lundkvist j. FEBS Open Bio. 2014 Apr 24;4:393-406. doi: 10.1016/j.fob.2014.04.006. eCollection 2014. FEBS Open Bio. 2014. PMID: 24918054 Free PMC article.
91 results