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Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. Glasgow A, et al. Among authors: lui i. bioRxiv [Preprint]. 2020 Aug 4:2020.07.31.231746. doi: 10.1101/2020.07.31.231746. bioRxiv. 2020. PMID: 32766586 Free PMC article. Updated. Preprint.
Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike.
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K; QCRG Structural Biology Consortium; Zhou XX, Leung KK, Wells JA. Bracken CJ, et al. Among authors: lui i. bioRxiv [Preprint]. 2020 Aug 10:2020.08.08.242511. doi: 10.1101/2020.08.08.242511. bioRxiv. 2020. PMID: 32817948 Free PMC article. Updated. Preprint.
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. Elledge SK, et al. Among authors: lui i. medRxiv [Preprint]. 2020 Aug 21:2020.08.17.20176925. doi: 10.1101/2020.08.17.20176925. medRxiv. 2020. PMID: 32839788 Free PMC article. Updated. Preprint.
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K; QCRG Structural Biology Consortium; Zhou XX, Leung KK, Wells JA. Bracken CJ, et al. Among authors: lui i. Nat Chem Biol. 2021 Jan;17(1):113-121. doi: 10.1038/s41589-020-00679-1. Epub 2020 Oct 20. Nat Chem Biol. 2021. PMID: 33082574 Free PMC article.
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Glasgow A, et al. Among authors: lui i. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28046-28055. doi: 10.1073/pnas.2016093117. Epub 2020 Oct 22. Proc Natl Acad Sci U S A. 2020. PMID: 33093202 Free PMC article.
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. Samelson AJ, et al. Among authors: lui i. bioRxiv [Preprint]. 2021 Sep 20:2021.01.19.427194. doi: 10.1101/2021.01.19.427194. bioRxiv. 2021. PMID: 33501440 Free PMC article. Updated. Preprint.
Mapping proteolytic neo-N termini at the surface of living cells.
Weeks AM, Byrnes JR, Lui I, Wells JA. Weeks AM, et al. Among authors: lui i. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018809118. doi: 10.1073/pnas.2018809118. Proc Natl Acad Sci U S A. 2021. PMID: 33536314 Free PMC article.
40 results