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Multidimensional definition of the interferonopathy of Down syndrome and its response to JAK inhibition.
Sci Adv. 2023 Jun 28;9(26):eadg6218. doi: 10.1126/sciadv.adg6218. Epub 2023 Jun 28.
Sci Adv. 2023.
PMID: 37379383
Free PMC article.
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Powers RK, Culp-Hill R, Ludwig MP, Smith KP, Waugh KA, Minter R, Tuttle KD, Lewis HC, Rachubinski AL, Granrath RE, Carmona-Iragui M, Wilkerson RB, Kahn DE, Joshi M, Lleó A, Blesa R, Fortea J, D'Alessandro A, Costello JC, Sullivan KD, Espinosa JM.
Powers RK, et al. Among authors: ludwig mp.
Nat Commun. 2019 Oct 18;10(1):4766. doi: 10.1038/s41467-019-12739-9.
Nat Commun. 2019.
PMID: 31628327
Free PMC article.
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JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.
Tuttle KD, Waugh KA, Araya P, Minter R, Orlicky DJ, Ludwig M, Andrysik Z, Burchill MA, Tamburini BAJ, Sempeck C, Smith K, Granrath R, Tracy D, Baxter J, Espinosa JM, Sullivan KD.
Tuttle KD, et al.
Cell Rep. 2020 Nov 17;33(7):108407. doi: 10.1016/j.celrep.2020.108407.
Cell Rep. 2020.
PMID: 33207208
Free PMC article.
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Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model.
Waugh KA, Minter R, Baxter J, Chi C, Galbraith MD, Tuttle KD, Eduthan NP, Kinning KT, Andrysik Z, Araya P, Dougherty H, Dunn LN, Ludwig M, Schade KA, Tracy D, Smith KP, Granrath RE, Busquet N, Khanal S, Anderson RD, Cox LL, Estrada BE, Rachubinski AL, Lyford HR, Britton EC, Fantauzzo KA, Orlicky DJ, Matsuda JL, Song K, Cox TC, Sullivan KD, Espinosa JM.
Waugh KA, et al.
Nat Genet. 2023 Jun;55(6):1034-1047. doi: 10.1038/s41588-023-01399-7. Epub 2023 Jun 5.
Nat Genet. 2023.
PMID: 37277650
Free PMC article.
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ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.
Abraham CG, Ludwig MP, Andrysik Z, Pandey A, Joshi M, Galbraith MD, Sullivan KD, Espinosa JM.
Abraham CG, et al. Among authors: ludwig mp.
Cell Rep. 2018 Sep 18;24(12):3224-3236. doi: 10.1016/j.celrep.2018.08.058.
Cell Rep. 2018.
PMID: 30232004
Free PMC article.
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Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway.
Ludwig MP, Galbraith MD, Eduthan NP, Hill AA, Clay MR, Tellez CM, Wilky BA, Elias A, Espinosa JM, Sullivan KD.
Ludwig MP, et al.
Cancer Res. 2023 Aug 1;83(15):2543-2556. doi: 10.1158/0008-5472.CAN-22-3173.
Cancer Res. 2023.
PMID: 37205634
Free PMC article.
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Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.
Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A.
Fitzwalter BE, et al.
Dev Cell. 2018 Mar 12;44(5):555-565.e3. doi: 10.1016/j.devcel.2018.02.014.
Dev Cell. 2018.
PMID: 29533771
Free PMC article.
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Screening for stress-resistance mutations in the mouse.
Chick WS, Ludwig M, Zhao X, Kitzenberg D, Williams K, Johnson TE.
Chick WS, et al.
Front Genet. 2014 Sep 8;5:310. doi: 10.3389/fgene.2014.00310. eCollection 2014.
Front Genet. 2014.
PMID: 25250048
Free PMC article.
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