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The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition.
Xiong C, Yang G, Kumar S, Aggarwal S, Leustik M, Snead C, Hamacher J, Fischer B, Umapathy NS, Hossain H, Wendel A, Catravas JD, Verin AD, Fulton D, Black SM, Chakraborty T, Lucas R. Xiong C, et al. Among authors: lucas r. Vascul Pharmacol. 2010 May-Jun;52(5-6):207-13. doi: 10.1016/j.vph.2009.12.010. Epub 2010 Jan 13. Vascul Pharmacol. 2010. PMID: 20074664 Free PMC article.
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability.
Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chakraborty T. Lucas R, et al. Am J Respir Cell Mol Biol. 2012 Oct;47(4):445-53. doi: 10.1165/rcmb.2011-0332OC. Epub 2012 May 10. Am J Respir Cell Mol Biol. 2012. PMID: 22582175 Free PMC article.
AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na(+) current in primary dog, pig and rat alveolar type II cells.
Tzotzos S, Fischer B, Fischer H, Pietschmann H, Lucas R, Dupré G, Lemmens-Gruber R, Hazemi P, Prymaka V, Shabbir W. Tzotzos S, et al. Among authors: lucas r. Pulm Pharmacol Ther. 2013 Jun;26(3):356-63. doi: 10.1016/j.pupt.2012.12.011. Epub 2013 Jan 9. Pulm Pharmacol Ther. 2013. PMID: 23313096 Free PMC article.
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. Czikora I, et al. Among authors: lucas r. Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC. Am J Respir Crit Care Med. 2014. PMID: 25029038 Free PMC article.
Glycosylation-dependent activation of epithelial sodium channel by solnatide.
Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R. Shabbir W, et al. Among authors: lucas r. Biochem Pharmacol. 2015 Dec 15;98(4):740-53. doi: 10.1016/j.bcp.2015.08.003. Epub 2015 Aug 5. Biochem Pharmacol. 2015. PMID: 26254591
The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. Lucas R, et al. J Biol Chem. 2016 Nov 4;291(45):23440-23451. doi: 10.1074/jbc.M116.718163. Epub 2016 Sep 19. J Biol Chem. 2016. PMID: 27645999 Free PMC article.
1,856 results