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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Laudette M, Sainte-Marie Y, Cousin G, Bergonnier D, Belhabib I, Brun S, Formoso K, Laib L, Tortosa F, Bergoglio C, Marcheix B, Borén J, Lairez O, Fauconnier J, Lucas A, Mialet-Perez J, Moro C, Lezoualc'h F. Laudette M, et al. Among authors: lucas a. Cell Death Dis. 2021 Sep 1;12(9):824. doi: 10.1038/s41419-021-04113-9. Cell Death Dis. 2021. PMID: 34471096 Free PMC article.
The cAMP binding protein Epac regulates cardiac myofilament function.
Cazorla O, Lucas A, Poirier F, Lacampagne A, Lezoualc'h F. Cazorla O, et al. Among authors: lucas a. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14144-9. doi: 10.1073/pnas.0812536106. Epub 2009 Aug 6. Proc Natl Acad Sci U S A. 2009. PMID: 19666481 Free PMC article.
Epac enhances excitation-transcription coupling in cardiac myocytes.
Pereira L, Ruiz-Hurtado G, Morel E, Laurent AC, Métrich M, Domínguez-Rodríguez A, Lauton-Santos S, Lucas A, Benitah JP, Bers DM, Lezoualc'h F, Gómez AM. Pereira L, et al. Among authors: lucas a. J Mol Cell Cardiol. 2012 Jan;52(1):283-91. doi: 10.1016/j.yjmcc.2011.10.016. Epub 2011 Oct 29. J Mol Cell Cardiol. 2012. PMID: 22056318 Free PMC article.
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
Bisserier M, Berthouze-Duquesnes M, Breckler M, Tortosa F, Fazal L, de Régibus A, Laurent AC, Varin A, Lucas A, Branchereau M, Marck P, Schickel JN, Deloménie C, Cazorla O, Soulas-Sprauel P, Crozatier B, Morel E, Heymes C, Lezoualc'h F. Bisserier M, et al. Among authors: lucas a. Circulation. 2015 Jan 27;131(4):390-400; discussion 400. doi: 10.1161/CIRCULATIONAHA.114.010686. Epub 2014 Nov 4. Circulation. 2015. PMID: 25369805
1,948 results