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Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors.
Birru W, Fernley RT, Graham LD, Grusovin J, Hill RJ, Hofmann A, Howell L, James PJ, Jarvis KE, Johnson WM, Jones DA, Leitner C, Liepa AJ, Lovrecz GO, Lu L, Nearn RH, O'Driscoll BJ, Phan T, Pollard M, Turner KA, Winkler DA. Birru W, et al. Among authors: lu l. Bioorg Med Chem. 2010 Aug 1;18(15):5647-60. doi: 10.1016/j.bmc.2010.06.020. Epub 2010 Jun 15. Bioorg Med Chem. 2010. PMID: 20619664
Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits.
Ren B, Peat TS, Streltsov VA, Pollard M, Fernley R, Grusovin J, Seabrook S, Pilling P, Phan T, Lu L, Lovrecz GO, Graham LD, Hill RJ. Ren B, et al. Among authors: lu l. Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1954-64. doi: 10.1107/S1399004714009626. Epub 2014 Jun 29. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25004972
A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.
Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J. Macdonald WA, et al. Among authors: lu l. J Exp Med. 2003 Sep 1;198(5):679-91. doi: 10.1084/jem.20030066. Epub 2003 Aug 25. J Exp Med. 2003. PMID: 12939341 Free PMC article.
Development of novel activin-targeted therapeutics.
Chen JL, Walton KL, Al-Musawi SL, Kelly EK, Qian H, La M, Lu L, Lovrecz G, Ziemann M, Lazarus R, El-Osta A, Gregorevic P, Harrison CA. Chen JL, et al. Among authors: lu l. Mol Ther. 2015 Mar;23(3):434-44. doi: 10.1038/mt.2014.221. Epub 2014 Nov 17. Mol Ther. 2015. PMID: 25399825 Free PMC article.
IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.
Wang H, Kjer-Nielsen L, Shi M, D'Souza C, Pediongco TJ, Cao H, Kostenko L, Lim XY, Eckle SBG, Meehan BS, Zhu T, Wang B, Zhao Z, Mak JYW, Fairlie DP, Teng MWL, Rossjohn J, Yu D, de St Groth BF, Lovrecz G, Lu L, McCluskey J, Strugnell RA, Corbett AJ, Chen Z. Wang H, et al. Among authors: lu l. Sci Immunol. 2019 Nov 15;4(41):eaaw0402. doi: 10.1126/sciimmunol.aaw0402. Sci Immunol. 2019. PMID: 31732518
Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.
Pyankov OV, Setoh YX, Bodnev SA, Edmonds JH, Pyankova OG, Pyankov SA, Pali G, Belford S, Lu L, La M, Lovrecz G, Volchkova VA, Chappell KJ, Watterson D, Marsh G, Young PR, Agafonov AA, Farmer JF, Volchkov VE, Suhrbier A, Khromykh AA. Pyankov OV, et al. Among authors: lu l. Sci Rep. 2017 Feb 3;7:41537. doi: 10.1038/srep41537. Sci Rep. 2017. PMID: 28155869 Free PMC article.
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