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Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial.
Butler CC, Hobbs FDR, Gbinigie OA, Rahman NM, Hayward G, Richards DB, Dorward J, Lowe DM, Standing JF, Breuer J, Khoo S, Petrou S, Hood K, Nguyen-Van-Tam JS, Patel MG, Saville BR, Marion J, Ogburn E, Allen J, Rutter H, Francis N, Thomas NPB, Evans P, Dobson M, Madden TA, Holmes J, Harris V, Png ME, Lown M, van Hecke O, Detry MA, Saunders CT, Fitzgerald M, Berry NS, Mwandigha L, Galal U, Mort S, Jani BD, Hart ND, Ahmed H, Butler D, McKenna M, Chalk J, Lavallee L, Hadley E, Cureton L, Benysek M, Andersson M, Coates M, Barrett S, Bateman C, Davies JC, Raymundo-Wood I, Ustianowski A, Carson-Stevens A, Yu LM, Little P; PANORAMIC Trial Collaborative Group. Butler CC, et al. Among authors: lowe dm. Lancet. 2023 Jan 28;401(10373):281-293. doi: 10.1016/S0140-6736(22)02597-1. Epub 2022 Dec 22. Lancet. 2023. PMID: 36566761 Free PMC article. Clinical Trial.
Norovirus infection in primary immune deficiency.
Brown LK, Clark I, Brown JR, Breuer J, Lowe DM. Brown LK, et al. Among authors: lowe dm. Rev Med Virol. 2017 May;27(3):e1926. doi: 10.1002/rmv.1926. Epub 2017 Mar 8. Rev Med Virol. 2017. PMID: 28271593 Review.
Mutagenesis in Norovirus in Response to Favipiravir Treatment.
Ruis C, Brown LK, Roy S, Atkinson C, Williams R, Burns SO, Yara-Romero E, Jacobs M, Goldstein R, Breuer J, Lowe DM. Ruis C, et al. Among authors: lowe dm. N Engl J Med. 2018 Nov 29;379(22):2173-2176. doi: 10.1056/NEJMc1806941. N Engl J Med. 2018. PMID: 30485769 Free article. No abstract available.
Viral infection in primary antibody deficiency syndromes.
Jones TPW, Buckland M, Breuer J, Lowe DM. Jones TPW, et al. Among authors: lowe dm. Rev Med Virol. 2019 Jul;29(4):e2049. doi: 10.1002/rmv.2049. Epub 2019 Apr 24. Rev Med Virol. 2019. PMID: 31016825 Review.
Persistent SARS-CoV-2 infection: the urgent need for access to treatment and trials.
Moran E, Cook T, Goodman AL, Gupta RK, Jolles S, Menon DK, Roberts DJ, Savic S, Shankar-Hari M, Brown M, Lowe DM. Moran E, et al. Among authors: lowe dm. Lancet Infect Dis. 2021 Oct;21(10):1345-1347. doi: 10.1016/S1473-3099(21)00464-3. Epub 2021 Aug 16. Lancet Infect Dis. 2021. PMID: 34411531 Free PMC article. No abstract available.
Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19.
Lowe DM, Brown LK, Chowdhury K, Davey S, Yee P, Ikeji F, Ndoutoumou A, Shah D, Lennon A, Rai A, Agyeman AA, Checkley A, Longley N, Dehbi HM, Freemantle N, Breuer J, Standing JF; FLARE Investigators. Lowe DM, et al. PLoS Med. 2022 Oct 19;19(10):e1004120. doi: 10.1371/journal.pmed.1004120. eCollection 2022 Oct. PLoS Med. 2022. PMID: 36260627 Free PMC article. Clinical Trial.
Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease.
Gbinigie O, Ogburn E, Allen J, Dorward J, Dobson M, Madden TA, Yu LM, Lowe DM, Rahman N, Petrou S, Richards D, Hood K, Patel M, Saville BR, Marion J, Holmes J, Png ME, Hayward G, Lown M, Harris V, Jani B, Hart N, Khoo S, Rutter H, Chalk J, Standing JF, Breuer J, Lavallee L, Hadley E, Cureton L, Benysek M, Andersson MI, Francis N, Thomas NPB, Evans P, van Hecke O, Koshkouei M, Coates M, Barrett S, Bateman C, Davies J, Raymundo-Wood I, Ustianowski A, Nguyen-Van-Tam J, Carson-Stevens A, Hobbs R, Little P, Butler CC. Gbinigie O, et al. Among authors: lowe dm. BMJ Open. 2023 Aug 7;13(8):e069176. doi: 10.1136/bmjopen-2022-069176. BMJ Open. 2023. PMID: 37550022 Free PMC article.
125 results