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Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen.
Bajoria S, Kumru OS, Doering J, Berman K, Slyke GV, Prigodich A, Rodriguez-Aponte SA, Kleanthous H, Love JC, Mantis NJ, Joshi SB, Volkin DB. Bajoria S, et al. Among authors: love jc. Vaccines (Basel). 2023 May 26;11(6):1030. doi: 10.3390/vaccines11061030. Vaccines (Basel). 2023. PMID: 37376419 Free PMC article.
Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine.
Kaur K, Xiong J, Sawant N, Agarwal S, Hickey JM, Holland DA, Mukhopadhyay TK, Brady JR, Dalvie NC, Tracey MK, Love KR, Love JC, Weis DD, Joshi SB, Volkin DB. Kaur K, et al. Among authors: love kr, love jc. J Pharm Sci. 2021 Mar;110(3):1054-1066. doi: 10.1016/j.xphs.2020.11.033. Epub 2020 Dec 3. J Pharm Sci. 2021. PMID: 33278412 Free PMC article.
Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens.
Sawant N, Kaur K, Holland DA, Hickey JM, Agarwal S, Brady JR, Dalvie NC, Tracey MK, Velez-Suberbie ML, Morris SA, Jacob SI, Bracewell DG, Mukhopadhyay TK, Love KR, Love JC, Joshi SB, Volkin DB. Sawant N, et al. Among authors: love kr, love jc. J Pharm Sci. 2021 Mar;110(3):1042-1053. doi: 10.1016/j.xphs.2020.11.039. Epub 2020 Dec 5. J Pharm Sci. 2021. PMID: 33285182 Free PMC article.
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru O, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Dalvie NC, et al. Among authors: love kr, love jc. bioRxiv [Preprint]. 2021 Mar 4:2021.03.03.433558. doi: 10.1101/2021.03.03.433558. bioRxiv. 2021. PMID: 33688647 Free PMC article. Updated. Preprint.
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii.
Dalvie NC, Biedermann AM, Rodriguez-Aponte SA, Naranjo CA, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Johnston RS, Crowell LE, Castelino S, Tracey MK, Whittaker CA, Love JC. Dalvie NC, et al. Among authors: love jc. bioRxiv [Preprint]. 2021 Apr 15:2021.04.15.440035. doi: 10.1101/2021.04.15.440035. bioRxiv. 2021. PMID: 33880471 Free PMC article. Updated. Preprint.
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.
Dalvie NC, Brady JR, Crowell LE, Tracey MK, Biedermann AM, Kaur K, Hickey JM, Kristensen DL 2nd, Bonnyman AD, Rodriguez-Aponte SA, Whittaker CA, Bok M, Vega C, Mukhopadhyay TK, Joshi SB, Volkin DB, Parreño V, Love KR, Love JC. Dalvie NC, et al. Among authors: love kr, love jc. Microb Cell Fact. 2021 May 1;20(1):94. doi: 10.1186/s12934-021-01583-6. Microb Cell Fact. 2021. PMID: 33933073 Free PMC article.
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Dalvie NC, et al. Among authors: love kr, love jc. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2106845118. doi: 10.1073/pnas.2106845118. Proc Natl Acad Sci U S A. 2021. PMID: 34493582 Free PMC article.
Modular development enables rapid design of media for alternative hosts.
Biedermann AM, Gengaro IR, Rodriguez-Aponte SA, Love KR, Love JC. Biedermann AM, et al. Among authors: love kr, love jc. Biotechnol Bioeng. 2022 Jan;119(1):59-71. doi: 10.1002/bit.27947. Epub 2021 Oct 18. Biotechnol Bioeng. 2022. PMID: 34596238 Free PMC article.
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.
Dalvie NC, Biedermann AM, Rodriguez-Aponte SA, Naranjo CA, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Johnston RS, Crowell LE, Castelino S, Tracey MK, Whittaker CA, Love JC. Dalvie NC, et al. Among authors: love jc. Biotechnol Bioeng. 2022 Feb;119(2):657-662. doi: 10.1002/bit.27979. Epub 2021 Nov 15. Biotechnol Bioeng. 2022. PMID: 34780057 Free PMC article.
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2.
Rodrigues KA, Rodriguez-Aponte SA, Dalvie NC, Lee JH, Abraham W, Carnathan DG, Jimenez LE, Ngo JT, Chang JYH, Zhang Z, Yu J, Chang A, Nakao C, Goodwin B, Naranjo CA, Zhang L, Silva M, Barouch DH, Silvestri G, Crotty S, Love JC, Irvine DJ. Rodrigues KA, et al. Among authors: love jc. Sci Adv. 2021 Dec 10;7(50):eabj6538. doi: 10.1126/sciadv.abj6538. Epub 2021 Dec 8. Sci Adv. 2021. PMID: 34878851 Free PMC article.
194 results