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Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
Wu L, Seung E, Xu L, Rao E, Lord DM, Wei RR, Cortez-Retamozo V, Ospina B, Posternak V, Ulinski G, Piepenhagen P, Francesconi E, El-Murr N, Beil C, Kirby P, Li A, Fretland J, Vicente R, Deng G, Dabdoubi T, Cameron B, Bertrand T, Ferrari P, Pouzieux S, Lemoine C, Prades C, Park A, Qiu H, Song Z, Zhang B, Sun F, Chiron M, Rao S, Radošević K, Yang ZY, Nabel GJ. Wu L, et al. Among authors: lord dm. Nat Cancer. 2020 Jan;1(1):86-98. doi: 10.1038/s43018-019-0004-z. Epub 2019 Nov 18. Nat Cancer. 2020. PMID: 35121834
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Xu L, Pegu A, Rao E, Doria-Rose N, Beninga J, McKee K, Lord DM, Wei RR, Deng G, Louder M, Schmidt SD, Mankoff Z, Wu L, Asokan M, Beil C, Lange C, Leuschner WD, Kruip J, Sendak R, Kwon YD, Zhou T, Chen X, Bailer RT, Wang K, Choe M, Tartaglia LJ, Barouch DH, O'Dell S, Todd JP, Burton DR, Roederer M, Connors M, Koup RA, Kwong PD, Yang ZY, Mascola JR, Nabel GJ. Xu L, et al. Among authors: lord dm. Science. 2017 Oct 6;358(6359):85-90. doi: 10.1126/science.aan8630. Epub 2017 Sep 20. Science. 2017. PMID: 28931639 Free PMC article.
A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K. Stefano JE, et al. Among authors: lord dm. J Biol Chem. 2020 Dec 25;295(52):18379-18389. doi: 10.1074/jbc.RA120.012395. Epub 2020 Oct 29. J Biol Chem. 2020. PMID: 33122192 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33453841
Bringing the Heavy Chain to Light: Creating a Symmetric, Bivalent IgG-Like Bispecific.
Ramasubramanian A, Tennyson R, Magnay M, Kathuria S, Travaline T, Jain A, Lord DM, Salemi M, Sullivan C, Magnay T, Hu J, Bric-Furlong E, Rival P, Zhou Y, Hoffmann D, Brondyk W, Radošević K, Chowdhury PS. Ramasubramanian A, et al. Among authors: lord dm. Antibodies (Basel). 2020 Nov 6;9(4):62. doi: 10.3390/antib9040062. Antibodies (Basel). 2020. PMID: 33172091 Free PMC article.
17 results