Lordén G - Search Results

1

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: lorden g. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.

2

Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation.

Callender JA, Yang Y, Lordén G, Stephenson NL, Jones AC, Brognard J, Newton AC. Callender JA, et al. Among authors: lorden g. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5497-E5505. doi: 10.1073/pnas.1805046115. Epub 2018 May 29. Proc Natl Acad Sci U S A. 2018. PMID: 29844158 Free PMC article.

3

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.

Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. Cohen Katsenelson K, et al. Among authors: lorden g. Elife. 2019 Aug 13;8:e48609. doi: 10.7554/eLife.48609. Elife. 2019. PMID: 31408005 Free PMC article.

4

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC, Newton AC. Kawashima AT, et al. Among authors: lorden g. Mol Cell Biol. 2021 Feb 23;41(3):e0033320. doi: 10.1128/MCB.00333-20. Epub 2021 Jan 4. Mol Cell Biol. 2021. PMID: 33397691 Free PMC article.

5

Protein kinase C fusion proteins are paradoxically loss of function in cancer.

Van AN, Kunkel MT, Baffi TR, Lordén G, Antal CE, Banerjee S, Newton AC. Van AN, et al. Among authors: lorden g. J Biol Chem. 2021 Jan-Jun;296:100445. doi: 10.1016/j.jbc.2021.100445. Epub 2021 Feb 20. J Biol Chem. 2021. PMID: 33617877 Free PMC article.

6

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Lordén G, Newton AC. Lordén G, et al. Neuronal Signal. 2021 Oct 8;5(4):NS20210036. doi: 10.1042/NS20210036. eCollection 2021 Dec. Neuronal Signal. 2021. PMID: 34737895 Free PMC article. Review.

7

[No title available]

[No authors listed] [No authors listed] PMID: 35553788

8

PHLPP Signaling in Immune Cells.

Lordén G, Lam AJ, Levings MK, Newton AC. Lordén G, et al. Curr Top Microbiol Immunol. 2022;436:117-143. doi: 10.1007/978-3-031-06566-8_5. Curr Top Microbiol Immunol. 2022. PMID: 36243842 Review.

9

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. Lordén G, et al. Nat Commun. 2022 Nov 23;13(1):7200. doi: 10.1038/s41467-022-34679-7. Nat Commun. 2022. PMID: 36418293 Free PMC article.

10

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

Lordén G, Sanjuán-García I, de Pablo N, Meana C, Alvarez-Miguel I, Pérez-García MT, Pelegrín P, Balsinde J, Balboa MA. Lordén G, et al. J Exp Med. 2017 Feb;214(2):511-528. doi: 10.1084/jem.20161452. Epub 2016 Dec 28. J Exp Med. 2017. PMID: 28031477 Free PMC article.

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