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Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A. Lopez JP, et al. Neuron. 2022 Jul 20;110(14):2283-2298.e9. doi: 10.1016/j.neuron.2022.05.001. Epub 2022 May 31. Neuron. 2022. PMID: 35649415 Free article.
miR-323a regulates ERBB4 and is involved in depression.
Fiori LM, Kos A, Lin R, Théroux JF, Lopez JP, Kühne C, Eggert C, Holzapfel M, Huettl RE, Mechawar N, Belzung C, Ibrahim EC, Chen A, Turecki G. Fiori LM, et al. Among authors: lopez jp. Mol Psychiatry. 2021 Aug;26(8):4191-4204. doi: 10.1038/s41380-020-00953-7. Epub 2020 Nov 20. Mol Psychiatry. 2021. PMID: 33219358 Free article.
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation.
Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A. Lopez JP, et al. Sci Adv. 2021 Jan 27;7(5):eabe4497. doi: 10.1126/sciadv.abe4497. Print 2021 Jan. Sci Adv. 2021. PMID: 33571131 Free PMC article.
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV. Häusl AS, et al. Among authors: lopez jp. Mol Psychiatry. 2021 Jul;26(7):3060-3076. doi: 10.1038/s41380-021-01044-x. Epub 2021 Mar 1. Mol Psychiatry. 2021. PMID: 33649453 Free PMC article.
SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants.
Lin R, Kos A, Lopez JP, Dine J, Fiori LM, Yang J, Ben-Efraim Y, Aouabed Z, Ibrahim P, Mitsuhashi H, Wong TP, Ibrahim EC, Belzung C, Blier P, Farzan F, Frey BN, Lam RW, Milev R, Muller DJ, Parikh SV, Soares C, Uher R, Nagy C, Mechawar N, Foster JA, Kennedy SH, Chen A, Turecki G. Lin R, et al. Among authors: lopez jp. Elife. 2023 Jul 11;12:e85316. doi: 10.7554/eLife.85316. Elife. 2023. PMID: 37432876 Free PMC article.
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.
Kos A, Lopez JP, Bordes J, de Donno C, Dine J, Brivio E, Karamihalev S, Luecken MD, Almeida-Correa S, Gasperoni S, Dick A, Miranda L, Büttner M, Stoffel R, Flachskamm C, Theis FJ, Schmidt MV, Chen A. Kos A, et al. Among authors: lopez jp. Sci Adv. 2023 Dec;9(48):eadj3793. doi: 10.1126/sciadv.adj3793. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039370 Free PMC article.
202 results