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Page 1
A senescence restriction point acting on chromatin integrates oncogenic signals.
Lopes-Paciencia S, Bourdeau V, Rowell MC, Amirimehr D, Guillon J, Kalegari P, Barua A, Quoc-Huy Trinh V, Azzi F, Turcotte S, Serohijos A, Ferbeyre G. Lopes-Paciencia S, et al. Cell Rep. 2024 Apr 23;43(4):114044. doi: 10.1016/j.celrep.2024.114044. Epub 2024 Apr 2. Cell Rep. 2024. PMID: 38568812 Free article.
The senescence-associated secretory phenotype and its regulation.
Lopes-Paciencia S, Saint-Germain E, Rowell MC, Ruiz AF, Kalegari P, Ferbeyre G. Lopes-Paciencia S, et al. Cytokine. 2019 May;117:15-22. doi: 10.1016/j.cyto.2019.01.013. Epub 2019 Feb 16. Cytokine. 2019. PMID: 30776684 Review.
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F. Del Toro N, et al. Among authors: lopes paciencia s. Cell Cycle. 2019 Mar-Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28. Cell Cycle. 2019. PMID: 30874462 Free PMC article.
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G. Igelmann S, et al. Among authors: lopes paciencia s. Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028. Mol Cell. 2021. PMID: 34547241 Free article.
Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer.
Rowell MC, Deschênes-Simard X, Lopes-Paciencia S, Le Calvé B, Kalegari P, Mignacca L, Fernandez-Ruiz A, Guillon J, Lessard F, Bourdeau V, Igelmann S, Duman AM, Stanom Y, Kottakis F, Deshpande V, Krizhanovsky V, Bardeesy N, Ferbeyre G. Rowell MC, et al. Among authors: lopes paciencia s. Cell Cycle. 2023 Oct;22(19):2172-2193. doi: 10.1080/15384101.2023.2278945. Epub 2023 Dec 5. Cell Cycle. 2023. PMID: 37942963
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Lessard F, et al. Among authors: lopes paciencia s. Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941930