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Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Mahoney SA, et al. Among authors: longtine ag. Aging Cell. 2024 Mar;23(3):e14060. doi: 10.1111/acel.14060. Epub 2023 Dec 7. Aging Cell. 2024. PMID: 38062873 Free PMC article.
Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.
Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Clayton ZS, et al. Among authors: longtine ag. Hypertension. 2023 Oct;80(10):2072-2087. doi: 10.1161/HYPERTENSIONAHA.123.21392. Epub 2023 Aug 18. Hypertension. 2023. PMID: 37593877
Female C57BL/6N mice are a viable model of aortic aging in women.
Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Longtine AG, et al. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H893-H904. doi: 10.1152/ajpheart.00120.2023. Epub 2023 Apr 28. Am J Physiol Heart Circ Physiol. 2023. PMID: 37115626