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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM. Wang Z, et al. Among authors: longo dl. Nat Med. 2019 Jan;25(1):141-151. doi: 10.1038/s41591-018-0221-5. Epub 2018 Nov 12. Nat Med. 2019. PMID: 30420753 Free PMC article.
Minimal PD-1 expression in mouse and human NK cells under diverse conditions.
Judge SJ, Dunai C, Aguilar EG, Vick SC, Sturgill IR, Khuat LT, Stoffel KM, Van Dyke J, Longo DL, Darrow MA, Anderson SK, Blazar BR, Monjazeb AM, Serody JS, Canter RJ, Murphy WJ. Judge SJ, et al. Among authors: longo dl. J Clin Invest. 2020 Jun 1;130(6):3051-3068. doi: 10.1172/JCI133353. J Clin Invest. 2020. PMID: 32134744 Free PMC article.
Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation.
Khuat LT, Le CT, Pai CS, Shields-Cutler RR, Holtan SG, Rashidi A, Parker SL, Knights D, Luna JI, Dunai C, Wang Z, Sturgill IR, Stoffel KM, Merleev AA, More SK, Maverakis E, Raybould HE, Chen M, Canter RJ, Monjazeb AM, Dave M, Ferrara JLM, Levine JE, Longo DL, Abedi M, Blazar BR, Murphy WJ. Khuat LT, et al. Among authors: longo dl. Sci Transl Med. 2020 Nov 25;12(571):eaay7713. doi: 10.1126/scitranslmed.aay7713. Sci Transl Med. 2020. PMID: 33239390 Free PMC article.
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ. Bouchlaka MN, et al. Among authors: longo dl. J Exp Med. 2013 Oct 21;210(11):2223-37. doi: 10.1084/jem.20131219. Epub 2013 Sep 30. J Exp Med. 2013. PMID: 24081947 Free PMC article.
Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
Mirsoian A, Bouchlaka MN, Sckisel GD, Chen M, Pai CC, Maverakis E, Spencer RG, Fishbein KW, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Taub DD, Murphy WJ. Mirsoian A, et al. Among authors: longo dl. J Exp Med. 2014 Nov 17;211(12):2373-83. doi: 10.1084/jem.20140116. Epub 2014 Nov 3. J Exp Med. 2014. PMID: 25366964 Free PMC article.
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
Sckisel GD, Bouchlaka MN, Monjazeb AM, Crittenden M, Curti BD, Wilkins DE, Alderson KA, Sungur CM, Ames E, Mirsoian A, Reddy A, Alexander W, Soulika A, Blazar BR, Longo DL, Wiltrout RH, Murphy WJ. Sckisel GD, et al. Among authors: longo dl. Immunity. 2015 Aug 18;43(2):240-50. doi: 10.1016/j.immuni.2015.06.023. Epub 2015 Jul 28. Immunity. 2015. PMID: 26231116 Free PMC article.
787 results