In vivo study of the role of α6-containing nicotinic acetylcholine receptor in retinal function using subtype-specific RDP-MII(E11R) toxin.
Barloscio D, Cerri E, Domenici L, Longhi R, Dallanoce C, Moretti M, Vilella A, Zoli M, Gotti C, Origlia N.
Barloscio D, et al. Among authors: longhi r.
FASEB J. 2017 Jan;31(1):192-202. doi: 10.1096/fj.201600855R. Epub 2016 Sep 28.
FASEB J. 2017.
PMID: 27682206
Because both the cortical and inner retina output were affected by RDP-MII(E11R), whereas photoreceptor output was preserved, we conclude that the reduced visual response was due to an alteration in the function of alpha6* nAChRs present in the ganglion cell layer.-Barloscio, D., …
Because both the cortical and inner retina output were affected by RDP-MII(E11R), whereas photoreceptor output was preserved, we conclude th …