Logan DT - Search Results

1

Ligand Sulfur Oxidation State Progressively Alters Galectin-3-Ligand Complex Conformations To Induce Affinity-Influencing Hydrogen Bonds.

Mahanti M, Pal KB, Kumar R, Schulze M, Leffler H, Logan DT, Nilsson UJ. Mahanti M, et al. Among authors: logan dt. J Med Chem. 2023 Nov 9;66(21):14716-14723. doi: 10.1021/acs.jmedchem.3c01223. Epub 2023 Oct 25. J Med Chem. 2023. PMID: 37878264 Free PMC article.

2

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ. Peterson K, et al. Among authors: logan dt. J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11. J Med Chem. 2018. PMID: 29284090 Free article.

3

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions.

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ. Zetterberg FR, et al. Among authors: logan dt. ChemMedChem. 2018 Jan 22;13(2):133-137. doi: 10.1002/cmdc.201700744. Epub 2018 Jan 15. ChemMedChem. 2018. PMID: 29194992

4

Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.

Kumar R, Peterson K, Misini Ignjatović M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Kumar R, et al. Among authors: logan dt. Org Biomol Chem. 2019 Jan 31;17(5):1081-1089. doi: 10.1039/c8ob02888e. Org Biomol Chem. 2019. PMID: 30632578

5

Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions.

Kumar R, Ignjatović MM, Peterson K, Olsson M, Leffler H, Ryde U, Nilsson UJ, Logan DT. Kumar R, et al. Among authors: logan dt. ChemMedChem. 2019 Aug 20;14(16):1528-1536. doi: 10.1002/cmdc.201900293. Epub 2019 Jul 11. ChemMedChem. 2019. PMID: 31246331 Free PMC article.

6

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.

Dahlqvist A, Mandal S, Peterson K, Håkansson M, Logan DT, Zetterberg FR, Leffler H, Nilsson UJ. Dahlqvist A, et al. Among authors: logan dt. Molecules. 2019 Dec 12;24(24):4554. doi: 10.3390/molecules24244554. Molecules. 2019. PMID: 31842451 Free PMC article.

7

Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C.

Wallerstein J, Ekberg V, Ignjatović MM, Kumar R, Caldararu O, Peterson K, Wernersson S, Brath U, Leffler H, Oksanen E, Logan DT, Nilsson UJ, Ryde U, Akke M. Wallerstein J, et al. Among authors: logan dt. JACS Au. 2021 Apr 1;1(4):484-500. doi: 10.1021/jacsau.0c00094. eCollection 2021 Apr 26. JACS Au. 2021. PMID: 34467311 Free PMC article.

8

The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics.

Saraboji K, Håkansson M, Genheden S, Diehl C, Qvist J, Weininger U, Nilsson UJ, Leffler H, Ryde U, Akke M, Logan DT. Saraboji K, et al. Among authors: logan dt. Biochemistry. 2012 Jan 10;51(1):296-306. doi: 10.1021/bi201459p. Epub 2011 Dec 7. Biochemistry. 2012. PMID: 22111949 Free PMC article.

9

Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C.

Manzoni F, Saraboji K, Sprenger J, Kumar R, Noresson AL, Nilsson UJ, Leffler H, Fisher SZ, Schrader TE, Ostermann A, Coates L, Blakeley MP, Oksanen E, Logan DT. Manzoni F, et al. Among authors: logan dt. Acta Crystallogr D Struct Biol. 2016 Nov 1;72(Pt 11):1194-1202. doi: 10.1107/S2059798316015540. Epub 2016 Oct 28. Acta Crystallogr D Struct Biol. 2016. PMID: 27841752 Free PMC article.

10

Designing interactions by control of protein-ligand complex conformation: tuning arginine-arene interaction geometry for enhanced electrostatic protein-ligand interactions.

Noresson AL, Aurelius O, Öberg CT, Engström O, Sundin AP, Håkansson M, Stenström O, Akke M, Logan DT, Leffler H, Nilsson UJ. Noresson AL, et al. Among authors: logan dt. Chem Sci. 2017 Dec 4;9(4):1014-1021. doi: 10.1039/c7sc04749e. eCollection 2018 Jan 28. Chem Sci. 2017. PMID: 29675148 Free PMC article.

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