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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.
Yu YR, Imrichova H, Wang H, Chao T, Xiao Z, Gao M, Rincon-Restrepo M, Franco F, Genolet R, Cheng WC, Jandus C, Coukos G, Jiang YF, Locasale JW, Zippelius A, Liu PS, Tang L, Bock C, Vannini N, Ho PC. Yu YR, et al. Among authors: locasale jw. Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5. Nat Immunol. 2020. PMID: 33020660
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Ho PC, et al. Among authors: locasale jw. Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27. Cell. 2015. PMID: 26321681 Free PMC article.
Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.
Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA. Davis RT, et al. Among authors: locasale jw. Nat Cell Biol. 2020 Mar;22(3):310-320. doi: 10.1038/s41556-020-0477-0. Epub 2020 Mar 6. Nat Cell Biol. 2020. PMID: 32144411
A reactive metabolite as an immune suppressant.
Ramesh V, Locasale JW. Ramesh V, et al. Among authors: locasale jw. Nat Immunol. 2020 May;21(5):497-498. doi: 10.1038/s41590-020-0664-y. Nat Immunol. 2020. PMID: 32327751 No abstract available.
216 results