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Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Cohen P, et al. Among authors: lo jc. Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021. Cell. 2014. PMID: 24439384 Free PMC article.
Adipsin is an adipokine that improves β cell function in diabetes.
Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Lo JC, et al. Cell. 2014 Jul 3;158(1):41-53. doi: 10.1016/j.cell.2014.06.005. Cell. 2014. PMID: 24995977 Free PMC article.
IRF4 is a key thermogenic transcriptional partner of PGC-1α.
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. Kong X, et al. Among authors: lo jc. Cell. 2014 Jul 3;158(1):69-83. doi: 10.1016/j.cell.2014.04.049. Cell. 2014. PMID: 24995979 Free PMC article.
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.
Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. Svensson KJ, et al. Among authors: lo jc. Cell Metab. 2016 Mar 8;23(3):454-66. doi: 10.1016/j.cmet.2016.01.008. Epub 2016 Feb 11. Cell Metab. 2016. PMID: 26876562 Free PMC article.
Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.
Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Khandekar MJ, et al. Among authors: lo jc. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):561-566. doi: 10.1073/pnas.1717776115. Epub 2018 Jan 2. Proc Natl Acad Sci U S A. 2018. PMID: 29295932 Free PMC article.
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. Gómez-Banoy N, et al. Among authors: lo jc. Nat Med. 2019 Nov;25(11):1739-1747. doi: 10.1038/s41591-019-0610-4. Epub 2019 Nov 7. Nat Med. 2019. PMID: 31700183 Free PMC article.
373 results